A Paradigm Shift To Prevent And Treat Alzheimer S Disease

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Author: Howard Friel
Publisher: Academic Press
ISBN: 012812279X
Size: 40.22 MB
Format: PDF, ePub
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A Paradigm Shift To Prevent And Treat Alzheimer S Disease by Howard Friel

Original Title: A Paradigm Shift To Prevent And Treat Alzheimer S Disease

A Paradigm Shift to Prevent and Treat Alzheimer’s Disease: From Monotargeting Pharmaceuticals to Pleiotropic Plant Polyphenols is the first book to systematically exhibit the powerful pleiotropic pharmacological effects on Alzheimer’s disease of plant-based compounds from ancient foods that humans have been consuming safely with substantial health benefits for thousands of years. These plant-based compounds include curcuminoids from turmeric, resveratrol from red wine and grape seed extract from other grape products, epigallocatechin-gallate (EGCG) from green tea, and oleocanthal and oleuropein from olive oil, in addition to a special extract, EGb 761, from the leaves of Ginkgo biloba, the oldest living species of tree on earth. This book also presents a new analytical framework that convincingly favors a multi-targeting ("pleiotropic") approach to the prevention and treatment of complex chronic diseases, in contrast to the mono-targeting of the pharmaceutical model. A Paradigm Shift to Prevent and Treat Alzheimer’s Disease is a unique and exciting resource for pharmaceutical scientists, pharmacologists, neurologists, general practitioners, research scientists in various medical and life sciences, healthcare professionals in clinical and executive positions, conventional medical schools, schools of naturopathic medicine, healthcare and medical journalists, executives in both national public healthcare systems and private insurers, and informed general readers. Presents carefully compiled evidence supporting the need to shift from pharmaceutical-based mono-targeting to plant polyphenol-based pleiotropic targeting for the prevention and treatment of Alzheimer’s disease Includes valuable tables that aggregate pleiotropic pharmacological effects of the plant polyphenols on Alzheimer’s disease-related pathogenic hallmarks Highlights regulatory aspects and discusses the challenges and potential solutions with respect to bioavailability of certain plant polyphenols

The End Of Alzheimer S

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Author: Dale Bredesen
Publisher: Penguin
ISBN: 0735216223
Size: 74.91 MB
Format: PDF
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The End Of Alzheimer S by Dale Bredesen

Original Title: The End Of Alzheimer S

The instant New York Times and Wall Street Journal bestseller A groundbreaking plan to prevent and reverse Alzheimer’s Disease that fundamentally changes how we understand cognitive decline. Everyone knows someone who has survived cancer, but until now no one knows anyone who has survived Alzheimer's Disease. In this paradigm shifting book, Dale Bredesen, MD, offers real hope to anyone looking to prevent and even reverse Alzheimer's Disease and cognitive decline. Revealing that AD is not one condition, as it is currently treated, but three, The End of Alzheimer’s outlines 36 metabolic factors (micronutrients, hormone levels, sleep) that can trigger "downsizing" in the brain. The protocol shows us how to rebalance these factors using lifestyle modifications like taking B12, eliminating gluten, or improving oral hygiene. The results are impressive. Of the first ten patients on the protocol, nine displayed significant improvement with 3-6 months; since then the protocol has yielded similar results with hundreds more. Now, The End of Alzheimer’s brings new hope to a broad audience of patients, caregivers, physicians, and treatment centers with a fascinating look inside the science and a complete step-by-step plan that fundamentally changes how we treat and even think about AD.

Alzheimer S Disease

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Author: Harald Hampel
Publisher: Karger Medical and Scientific Publishers
ISBN: 3805598025
Size: 47.34 MB
Format: PDF, ePub, Docs
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Alzheimer S Disease by Harald Hampel

Original Title: Alzheimer S Disease

How current biomarkers are modernizing the diagnosis of Alzheimer's disease Expanding knowledge on genetic and epigenetic risk factors is rapidly enhancing our understanding of the complex molecular interactions and systems involved in the pathogenesis of Alzheimer's disease. In this publication, leading experts discuss emerging novel conceptual models of the disease along with advances in the development of surrogate markers that will not only improve the accuracy of diagnostic technologies but also improve the prospects of developing disease-modifying interventions. The novel framework of the disease presented here highlights research on biological markers as well as efforts to validate technologies for early and accurate detection. It also introduces notion of a complex systems dysfunction that extends beyond prevailing ideas derived from the amyloid' or tau' hypotheses. This outstanding publication provides researchers, clinicians, students and other professionals interested in neurodegenerative disorders with a comprehensive update on current trends and future directions in therapy development, with special focus on advances in clinical trial designs.

Why Buddha Never Had Alzheimer S

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Author: Shuvendu Sen
Publisher: Health Communications, Inc.
ISBN: 0757319955
Size: 61.29 MB
Format: PDF, Mobi
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Why Buddha Never Had Alzheimer S by Shuvendu Sen

Original Title: Why Buddha Never Had Alzheimer S

Who among us is not affected by issues such as stress, depression, personality and behavioral changes, agitation, hypertension or high cholesterol--to name a few? Did you know that these are some of the cognitive and biological deficiencies that are associated with Alzheimer's? It is estimated that 5.4 million people in the U.S. are afflicted with Alzheimer's disease. In its capacity to completely destroy personalities, relationships and daily living, we cannot afford to continue thinking of it as a private disease. Alzheimer's is a family problem--ruthless in its scope and spread. And despite relentless trials and research studies, scientists have not found a drug to control it. Even worse, there isn't even a fully reliable diagnostic test for it. Alzheimer's disease has become a gigantic specter that looms before all of us as we age, and it is advancing unimpeded. Today we know that contributing factors and symptoms (such as stress and hypertension) can be alleviated with holistic, alternate management approaches--like meditation, yoga, music therapy and virtual reality therapy. Research studies from Harvard Medical School, Johns Hopkins University and Mayo Clinic, among many others, have demonstrated the comprehensive benefits of yoga and meditation on various aspects of the human mind--and when you think about it, that's where Alzheimer's disease develops--in the mind. But, how can meditation and yoga stop or even reverse the course of Alzheimer's? They set the mind on an inward journey where the risk factors that precipitate the disease are formed. This bridging of the old and new creates an imperative paradigm shift in our perspective toward Alzheimer's disease management. Why Buddha Never Had Alzheimer's is precisely what is needed to cause a drastic and necessary revolution in medical care.

Ferri S Clinical Advisor 2015

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Author: Fred F. Ferri
Publisher: Elsevier Health Sciences
ISBN: 0323084303
Size: 33.21 MB
Format: PDF, Kindle
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Ferri S Clinical Advisor 2015 by Fred F. Ferri

Original Title: Ferri S Clinical Advisor 2015

Ferri’s Clinical Advisor 2015 is the fastest, most effective way to access current diagnostic and therapeutic information on more than 700 common medical conditions. Dr. Ferri’s popular "5 books in 1" format provides quick guidance on short QT syndrome, microscopic polyangiitis, fungal meningitis, and much more. This medical reference makes the answers you need even easier to find - anytime, anywhere. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Review normal values and interpret results for more than 200 lab tests. Improve your family healthcare practice’s efficiency with cost-effective referral and consultation guidelines. Identify and treat a broader range of disorders, including diabetic foot infections, hypergonadism, and acute liver failure, with 22 new topics in the Diseases & Disorders section. Improve your interpretation of presenting symptoms with 38 new topics and 40 new images in the Differential Diagnosis section, and optimize patient care with more than 250 new figures and tables. Rapidly find the answers you need with separate sections on diseases and disorders, differential diagnosis, clinical algorithms, laboratory results, and clinical preventive services, plus an at-a-glance format that uses cross-references, outlines, bullets, tables, boxes, and algorithms to expedite your search. Expedite insurance reimbursements with current ICD-9 and future ICD-10 insurance billing codes. Access full-color images and more than 90 online-only topics at Expert Consult, as well as EBMs, Suggested Reading, Patient Teaching Guides, and additional algorithms.

The Spectrum Of Psychotic Disorders

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Author: Daryl Fujii
Publisher: Cambridge University Press
ISBN: 113946213X
Size: 63.28 MB
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The Spectrum Of Psychotic Disorders by Daryl Fujii

Original Title: The Spectrum Of Psychotic Disorders

The spectrum of psychotic disorders encompasses as many as 25 different etiologies, ranging from the primary psychoses through those secondary to medical conditions, drugs and medications, and sensory impairments. This 2007 book provides a one-stop, comprehensive review of these disorders and gives quick comparisons for diagnostic decision-making to help with difficult differential diagnoses. Every chapter is uniformly structured to show comparisons between each disorder of presentation, course, and underlying neuropathology. Evidence for each etiology is also rated, indicating the confidence level the reader can place in the current findings. The international team of authors also examines data supporting a unitary neurobiological model of psychosis and the hypothesis that psychosis is a neurobiological syndrome similar to aphasia or apraxia. This book represents a paradigm shift in understanding, classifying and diagnosing these disorders, providing directions for future research and treatment. It will be of great interest to psychiatrists and neuroscientists alike.

Dementia Care With Black And Latino Families

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Author: Delia J González Sanders, PhD LCSW
Publisher: Springer Publishing Company
ISBN: 0826106781
Size: 33.88 MB
Format: PDF
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Dementia Care With Black And Latino Families by Delia J González Sanders, PhD LCSW

Original Title: Dementia Care With Black And Latino Families

Designated a Doody's Core Title! "The authors have created a book that comfortably combines substantial research findings with readable, practical guidelines for assessment and intervention in the real-world practice of social work. This authoritatively researched, well-written volume will appeal to the multiple disciplines involved in assisting dementia patients and their families. It will also be useful for academic health care collections...Highly recommended."--Choice: Current Reviews for Academic Libraries Understanding the role of dementia caregivers in different ethnic and cultural contexts is one of the most important skills that social workers should master. This comprehensive volume provides practical guidance for social work professionals who work with Black and Latino families living with the daily challenges of Alzheimer's disease and other forms of dementia. It is grounded in the interpretation and meaning of dementia in Black and Latino cultural heritages, and based on both a solid theoretical framework and the substantial research and clinical expertise of the authors. Detailed, step-by-step guidelines to assessment and intervention in ethnic-specific situations provide useful strategies that go beyond generic solutions. The text presents an overview of the epidemiology and clinical course of dementia with a focus on those forms of the disease most common to Blacks and Latinos. It addresses family care and role responsibilities in ethnic families and their theoretical, ethnic, and cultural foundations. Self-efficacy and cognitive behavioral problem-solving theories are discussed as modalities of choice. The text also considers financial and service delivery trends and use of technology, and provides detailed forms, documents, and dementia care resources. Numerous case studies will help readers to quickly put information into the context of real-world situations. Key Features: Provides concrete, targeted interventions for assisting ethnic family caregivers in confronting day-to-day issues Explains how and why self-efficacy and cognitive behavioral problem-solving theories are particularly useful for social work with ethnic family caregivers Offers detailed, step-by-step guidelines to assessment and intervention Includes problem-solving forms, documents, and additional dementia care resources Contains vivid supporting case studies in each chapter

Principles Of Drug Therapy In Neurology

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Author: Michael V. Johnston
Publisher: OUP USA
Size: 71.90 MB
Format: PDF, Kindle
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Principles Of Drug Therapy In Neurology by Michael V. Johnston

Original Title: Principles Of Drug Therapy In Neurology

Since the first edition of this book was published in 1992, the number of pharmacological therapies available for treating neurological disorders has grown exponentially. This new edition brings the book fully up-to-date, and features PET scans to illustrate brain action, and new chapters on practical therapeutics and clinical trials.

Health Professional And Patient Interaction

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Author: Ruth B. Purtilo
Publisher: W.B. Saunders Company
ISBN: 9780721660486
Size: 74.82 MB
Format: PDF, ePub
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Health Professional And Patient Interaction by Ruth B. Purtilo

Original Title: Health Professional And Patient Interaction

This text focuses on the interaction between health professionals and patients. It explores sensitive ethnic, socioeconomic and religious complexities in order to emphasize diversity as the basis of understanding leading to respectful communication. Each chapter includes a set of teaching tools featuring learning objectives and questions aimed at helping readers to apply concepts to real-life situations. Value clarification exercises, humorous illustrations, poetry, literature and satire are also utilized to help the student reflect on his/her own commitment. This edition features two new chapters, on newborns, infants and toddlers, and on working with patients who are abusive, demanding, depressed or impaired. In addition, there is enhanced material on helping students become clinicians, new content in the verbal communication section and a new epilogue. The impact on patient interaction of evolving trends in health care (such as confidentiality and computerized health care data systems) is also discussed.

Chemistry And Molecular Aspects Of Drug Design And Action

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Author: E. A. Rekka
Publisher: CRC Press
ISBN: 9781420008272
Size: 18.98 MB
Format: PDF
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Chemistry And Molecular Aspects Of Drug Design And Action by E. A. Rekka

Original Title: Chemistry And Molecular Aspects Of Drug Design And Action

An ever-increasing demand for better drugs, elevated safety standards, and economic considerations have all led to a dramatic paradigm shift in the way that drugs are being discovered and developed. Known as rational drug design, this contemporary process is defined by three main steps: the discovery of lead compounds, surgical manipulation to develop pharmacophores, and further optimization to produce the best compounds. Chemistry and Molecular Aspects of Drug Design and Action brings together an impressive collection of world-renowned pharmacochemistry scientists who are currently defining the emergence of rational drug design. Offering insight from their own specialized research, these pioneers highlight the variety of approaches being employed in this field, including those that start by considering either molecular mechanisms of drug action, or the metabolizing enzyme action occurring in the structure of a drug molecule. Another approach they explore is one that starts from the pathobiochemistry and pathophysiology of target diseases. Furthermore, the book also considers drug development that makes use of already developed compounds stored in data banks. Divided into five parts, each dedicated to various aspects of the classical medicinal chemistry approach, the text makes it easy for readers to focus on a field of specific interest. Chemical, Biochemical, and Biological Aspects of Pathophysiological Conditions Classical Medicinal Chemistry Drug Design, Chemical and Molecular Aspects of Drug Action Drug Xenobiotic Metabolism Physical Organic and Theoretical Medicinal Chemistry While each section can be studied independently, the combined material in this volume provides the most comprehensive overview available on rational drug design. This work is an invaluable resource both for those entering the field, as well as those researchers looking to build on current progress.

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