Amylin

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Author: Andrew Young
Publisher: Gulf Professional Publishing
ISBN: 9780120329540
Size: 78.26 MB
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Amylin by Andrew Young


Original Title: Amylin

Amylin deciphers amylin's physiology and reveals previously unrecognized mechanisms fundamental to control body weight and fuel homeostasis. This book also discusses therapeutic utility of amylin as the first new medicine to treat diabetes since insulin. Provides a current comprehensive treatment of amylin the hormone Identifies the majority of amylin's physiologic functions

Physiology And Pharmacology Of Bone

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Author: Gregory R. Mundy
Publisher: Springer Science & Business Media
ISBN: 3642779913
Size: 22.57 MB
Format: PDF, ePub
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Physiology And Pharmacology Of Bone by Gregory R. Mundy


Original Title: Physiology And Pharmacology Of Bone

The authors, all accomplished and world-renowned experts in their topic areas, have provided controversial and up-to-date accounts of the current status of research in calcium and bone metabolism by reviewing major areas of basic science which have an impact on the understanding of bone diseases and related disorders.

Peptide Based Drug Discovery

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Author: Ved Srivastava
Publisher: Royal Society of Chemistry
ISBN: 1782627324
Size: 80.68 MB
Format: PDF, ePub
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Peptide Based Drug Discovery by Ved Srivastava


Original Title: Peptide Based Drug Discovery

With potentially high specificity and low toxicity, biologicals offer promising alternatives to small-molecule drugs. Peptide therapeutics have again become the focus of innovative drug development efforts backed up by a resurgence of venture funds and small biotechnology companies. What does it take to develop a peptide-based medicine? What are the key challenges and how are they overcome? What are emerging therapeutics for peptide modalities? This book answers these questions with a holistic story from molecules to medicine, combining the themes of design, synthesis and clinical applications of peptide-based therapeutics and biomarkers. Chapters are written and edited by leaders in the field from industry and academia and they cover the pharmacokinetics of peptide therapeutics, attributes necessary for commercially successful metabolic peptides, medicinal chemistry strategies for the design of peptidase-resistant peptide analogues, disease classes for which peptide therapeutic are most relevant, and regulatory issues and guidelines. The critical themes covered provide essential background information on what it takes to develop peptide-based medicine from a chemistry perspective and views on the future of peptide drugs. This book will be a valuable resource not only as a reference book for the researcher engaged in academic and pharmaceutical setting, from basic research to manufacturing and from organic chemistry to biotechnology, but also a valuable resource to graduate students to understand discovery and development process for peptide-based medicine.

Principles Of Pharmacology

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Author: David E. Golan
Publisher: Lippincott Williams & Wilkins
ISBN: 1608312704
Size: 16.83 MB
Format: PDF
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Principles Of Pharmacology by David E. Golan


Original Title: Principles Of Pharmacology

Now in its third edition, Principles of Pharmacology presents content in a conceptual framework that maximizes understanding and retention and minimizes rote memorization. It takes students "beyond the disease" and deep into physiologic, biochemical, and pathophysiologic systems where drugs activate or inhibit these systems by interacting with molecular and cellular targets. This unique approach ensures understanding of the mechanisms of drug actions on the body, and ultimately, in treating the human patient. Ideal for introductory pharmacology courses that emphasize critical thinking, molecular understanding, systems-based integration, and clinical preparation, the text: Features chapter-opening clinical cases and questions to establish a context for the discussion and the answers that follow Presents signature drug summary tables, updated and organized by mechanism of action, with information on clinical applications, adverse effects, contraindications, and therapeutic considerations Incorporates NEW full-color illustrations throughout, suiting the needs of visual learners and more effectively presenting concepts covered in the narrative Integrates timely content, including recently approved drugs as well as current research on drug mechanisms of action Delivers course and review material appropriate for students through a uniquely collaborative authorship consisting of medical students, residents, and faculty

The Cgrp Family

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Author: David Poyner
Publisher: CRC Press
ISBN:
Size: 50.70 MB
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The Cgrp Family by David Poyner


Original Title: The Cgrp Family

This book is based on presentations given at CGRP '98, the Third International Meeting on CGRP and related peptides held in the UK in May 1998. The principal speakers have each contributed a chapter and many of the short and poster communications will also be found here. This book follows from the tradition set by the First and Second Meetings in 1992 and 1995 when the proceedings were published. The work is aimed at the specialist in the field, but it is hoped that many of the chapters will also prove useful as introductions to those wishing to gain greater familiarity with the biology and pharmacology of these important peptides. The book begins with a broad overview of the field, past and present. It is followed by two chapters dealing with the "classical" pharmacology of CGRP. In particular there is an account of the pitfalls of the present generation of CGRP antagonists and the dangers of assuming that every action of CGRP is mediated by a CGRP receptor. However the bulk of this section is taken up by the recent developments concerning the cloning of receptors for CGRP and adrenomedullin. An exciting story is emerging of how a single molecule, calcitonin receptor-like receptor (CRLR), can mediate the response to both CGRP and adrenomedullin depending on the presence of different members of a family of accessory proteins, the Receptor Activity Modifying Proteins (RAMPs). This is covered in three chapters and is followed by an account of another accessory protein associated with CGRP responsiveness, Receptor Component Protein (RCP). Following sections of the book deal with the biochemistry, physiology and pharmacology of receptors for the allied peptides amylin and adrenomedullin. The close connections between amylin and calcitonin receptors are highlighted and role of amylin in the regulation of food intake is then considered. The molecular nature of adrenomedullin receptors is addressed in an earlier chapter but in this section their pharmacology is examined. The pathophysiology of CGRP and related peptides formed a significant part of the meeting. Three chapters examine the role of CGRP in vascular disorders, joint dysfunction and gastrointestinal pathology. A separate section considers the role of CGRP in headache and migraine. The book concludes with a selection of the short oral and poster communications and then an important appendix, reflecting a workshop held to discuss the nomenclature of CGRP, amylin and adrenomedullin receptors. As the majority of the active workers in the field were present at this meeting it is hoped that the consensus view presented here might be widely acceptable.

Pharmacology And Physiology For Anesthesia E Book

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Author: Hugh C. Hemmings
Publisher: Elsevier Health Sciences
ISBN: 1455737933
Size: 78.38 MB
Format: PDF, ePub, Docs
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Pharmacology And Physiology For Anesthesia E Book by Hugh C. Hemmings


Original Title: Pharmacology And Physiology For Anesthesia E Book

Better understand the complexities of pharmacology and physiology relevant to your practice with the brand-new medical reference book, Pharmacology and Physiology for Anesthesia. Drs. Hugh Hemmings and Talmage Egan provide the clinical insights you need to effectively administer anesthesia, ensuring patient safety and the most optimal outcomes. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Access comprehensive, continually updated research on the physiology of organ systems and clinical topics in the pharmacology of anesthetic drugs. Quickly and easily reference the information you need through user-friendly tables, figures, and algorithms, all presented in lavish full color throughout. Understand the molecular mechanism of drug actions and identify key drug interactions that may complicate anesthesia with dedicated sections on these key areas.

Instant Pharmacology

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Author: Kourosh Saeb-Parsy
Publisher: Wiley
ISBN: 9780471985983
Size: 74.24 MB
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Instant Pharmacology by Kourosh Saeb-Parsy


Original Title: Instant Pharmacology

Written by students, for students, Instant Pharmacology represents a novel approach to the study of pharmacology and provides an accessible and exhaustive, yet concise account of pharmacology. The book first introduces readers to the basic principles of pharmacodynamics and pharmacokinetics, which are obviously essential for understanding the action of all drugs, and it is subsequently divided into four parts. * Part One covers the main chemical transmitters which mediate all bodily processes and are the site of much pharmacological intervention. * A systematic account of the pharmacological treatment of major clinical conditions is presented in Part Two, where emphasis is placed primarily on the principles upon which therapy is based, rather than overshadowing these principles with detailed features of individual drugs. * Part Three comprises a Dictionary of Drugs, alphabetically listing all the drugs encountered in Parts One and Two. Entries in the dictionary describe in detail the clinical uses, mechanisms of action, pharmacokinetics and the main adverse effects of a specific agent. * Finally, to allow readers to evaluate their own progress in the subject, Part Four is a self assessment section, including multiple choice questions (with answers) covering all the topics in Instant Pharmacology. Instant Pharmacology will make the study of pharmacology a more rewarding and enjoyable process, and is essential reading for all undergraduate students of pharmacology, pharmacy and related courses, as well as preclinical medical and dental students.

Hormones And The Heart In Health And Disease

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Author: Leonard Share
Publisher: Springer Science & Business Media
ISBN: 1592597084
Size: 56.86 MB
Format: PDF
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Hormones And The Heart In Health And Disease by Leonard Share


Original Title: Hormones And The Heart In Health And Disease

The maintenance of arterial blood pressure and the distribution of blood flow to the various organs of the body depends on the control of the pumping action of the heart and of the resistance of the vascular beds in the individual organs in accordance with their metabolic needs. These controls are achieved through the integrated actions of circulat ing hormones, humoral factors that are synthesized and released in the heart and blood vessels, and the autonomic nervous system. The heart, however, is not only the target for the direct and indirect actions of a number of hormones and humoral factors, it is also an endocrine organ in the traditional sense, synthesizing and secreting into the circulation chemical factors that act at distant sites. In this treatise, Hormones and the Heart in Health and Disease, we interpret "endocrinology" broadly and consider traditional hormones as well as autocoids that are secreted by the heart or that act on it. In this overview, the relevant chapters are indicated in parentheses. The discovery of atrial natriuretic peptide (ANP; atrial natriuretic factor, ANF) in the 1980s indicated that the heart does indeed function as an endocrine organ in the classic sense. ANP (Chapter I) is synthesized in the heart and secreted into the circulation for actions on the kidney, where it is a potent natriuretic agent, and on the vasculature, where it causes vasodilation. ANP can also affect myocardial contractility.

Principles Of Bone Biology

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Author: John P. Bilezikian
Publisher: Academic Press
ISBN: 9780080568751
Size: 43.84 MB
Format: PDF, Kindle
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Principles Of Bone Biology by John P. Bilezikian


Original Title: Principles Of Bone Biology

Principles of Bone Biology provides the most comprehensive, authoritative reference on the study of bone biology and related diseases. It is the essential resource for anyone involved in the study of bone biology. Bone research in recent years has generated enormous attention, mainly because of the broad public health implications of osteoporosis and related bone disorders. Provides a "one-stop" shop. There is no need to search through many research journals or books to glean the information one wants...it is all in one source written by the experts in the field The essential resource for anyone involved in the study of bones and bone diseases Takes the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics Readers can easily search and locate information quickly as it will be online with this new edition

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