New Research On Autoantibodies

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Author: Claude T. Petrelli
Publisher: Nova Publishers
ISBN: 9781604560558
Size: 37.57 MB
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New Research On Autoantibodies by Claude T. Petrelli


Original Title: New Research On Autoantibodies

Autoantibodies are a group of antibodies (immune proteins) that mistakenly target and damage specific tissues or organs of the body. One or more autoantibodies may be produced by a person's immune system when it fails to distinguish between "self" and "non-self" proteins. Usually the immune system is able to discriminate by recognising foreign substances (non-self) and ignoring the body's own cells (self), yet not overreact to non-threatening substances such as foods, dust and pollen, or beneficial microorganisms. It creates antibodies only when it perceives what it has been exposed to as a threat (non-self). When the immune system ceases to recognise one or more of the body's normal constituents as "self", it may produce autoantibodies that attack its own cells, tissues, and/or organs, causing inflammation and damage. The causes of this inappropriate action are varied and are not well understood, often resulting in a chronic auto-immune disorder. While there is not a direct link, it is thought that many cases of autoantibody production are due to a genetic predisposition combined with an environmental trigger (such as a viral illness or a prolonged exposure to certain toxic chemicals). Some families have been shown to have a high prevalence of auto-immune conditions; however, individual family members may have different auto-immune disorders or may never develop an auto-immune condition. Researchers believe that there may also be a hormonal component to the cause as many of the auto-immune conditions are more common in women of childbearing age. This book presents leading research from throughout the world.

Autoantibodies

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Author: Yehuda Shoenfeld
Publisher: Newnes
ISBN: 0444593772
Size: 52.44 MB
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Autoantibodies by Yehuda Shoenfeld


Original Title: Autoantibodies

Autoimmune diseases are characterized by the occurrence of antibodies reacting with self-constituents of the body. The fully updated third edition of Autoantibodies is an in-depth review of the main autoantibodies identified up to now, with particular emphasis on those that display a diagnostic or prognostic clinical value. The new edition covers recent scientific advances, diagnostic techniques, and therapeutic technologies. Each chapter is focused on a single family of autoantibodies. This important reference contains historical notes, definitions, origins and sources of antigens recognized genetic associations, mediated pathogenic mechanisms, methods of detection, as well as clinical utility (disease prevalence and association, diagnostic value, sensitivity and specificity, prognostic value). This is an ideal reference for anyone involved in the field of autoimmune diseases. Presents all known, important autoantibodies in a single source, focusing on the antibodies needed for autoimmune disorder diagnosis Includes clinical applications for each autoantibody along with general information Organized by disease and disorder type, by autoantibody family, and completely cross-referenced

Autoantibodies Research Progress

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Author: Quentin P. Dubois
Publisher: Nova Publishers
ISBN: 9781604561081
Size: 77.90 MB
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Autoantibodies Research Progress by Quentin P. Dubois


Original Title: Autoantibodies Research Progress

An autoantibody is an antibody (a type of protein) manufactured by the immune system that is directed against one or more of the individual's own proteins. Many autoimmune diseases in humans, most notably lupus erythematosus, are caused by such autoantibodies. This book presents the latest research from around the world.

Autoantibodies And Autoimmunity

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Author: Kenneth Michael Pollard
Publisher: John Wiley & Sons
ISBN: 3527607226
Size: 38.78 MB
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Autoantibodies And Autoimmunity by Kenneth Michael Pollard


Original Title: Autoantibodies And Autoimmunity

This is the first book to address all aspects of the biology of autoantibodies in a single volume, including a discussion of immunology, experimental models, clinical aspects, and the use of autoantibodies as probes in molecular and cellular biology. The editor, currently professor at the W.M. Keck Autoimmune Disease Center of The Scripps Research Institute, has assembled an all-star team of authors to report on the latest research, technologies, and applications. Following an introductory chapter, the book goes on to cover such topics as cellular mechanisms of autoantibody production, clinical and diagnostic usefulness in human disease, and animal models used to study the elicitation of autoantibodies. The whole is rounded off with a look at future perspectives. With its comprehensive coverage, this volume will appeal not only to immunologists and clinicians but also to cell and molecular biologists.

Natural Autoantibodies

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Author: Yehuda Shoenfeld
Publisher: CRC Press
ISBN: 9780849355011
Size: 31.58 MB
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Natural Autoantibodies by Yehuda Shoenfeld


Original Title: Natural Autoantibodies

Natural Autoantibodies provides an in-depth analysis of all aspects of natural antibodies. The book examines the advantages and pitfalls of every type of technique that is widely used for detecting autoantibodies. It also covers the sequencing of human autoantibody genes, discussing how sequencing is undertaken and the genetic clues available to elucidate the genetic origins of autoimmunity. Animal models of autoimmunity are also covered, and the up-to-date account provided in this book explains how natural autoantibodies have important regulatory functions and also occasionally serve as templates for autoimmunity. Other topics examined in Natural Autoantibodies: Their Physiological Role and Regulatory Significance include idiotypes of natural autoantibodies; the pathogenic role of natural autoantibodies; and methods to measure the effects of genetic and sex hormones, as well as aging, on natural autoantibodies. The book will be an excellent research tool and reference for immunologists, rheumatologists, and others interested in the topic.

Autoantibodies Advances In Research And Application 2012 Edition

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Author:
Publisher: ScholarlyEditions
ISBN: 1481640356
Size: 13.97 MB
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Autoantibodies Advances In Research And Application 2012 Edition by


Original Title: Autoantibodies Advances In Research And Application 2012 Edition

Autoantibodies—Advances in Research and Application: 2012 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Autoantibodies in a compact format. The editors have built Autoantibodies—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Autoantibodies in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Autoantibodies—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Autoantibodies

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Author: Graham E. Jenkins
Publisher: Nova Biomedical
ISBN: 9781620815601
Size: 31.46 MB
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Autoantibodies by Graham E. Jenkins


Original Title: Autoantibodies

Autoantibodies that are directed against self antigens are called autoantibodies. Not all autoantibodies are harmful. Autoantibodies can be useful in the removal of cell debris during inflammation. Some autoantibodies may be the actual pathogenic agents of autoimmune disease, the secondary consequences of tissue damage, or the harmless footprints of an etiologic agent. In this book, the authors present current research in the detection, pathogenicity and health implications of autoantibodies. Topics include the implicated autoantibodies in kidney disease and Alzheimer's disease; autoimmunity in cardiovascular disease; detection and analysis of natural autoantibodies; and B Cells and autoantibodies in multiple sclerosis.

Anti Factor Xiii A Subunit Fxiii A Autoantibodies Block Fxiii A2b2 Assembly And Steal Fxiii A From Native Fxiii A2b2

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Anti Factor Xiii A Subunit Fxiii A Autoantibodies Block Fxiii A2b2 Assembly And Steal Fxiii A From Native Fxiii A2b2 by


Original Title: Anti Factor Xiii A Subunit Fxiii A Autoantibodies Block Fxiii A2b2 Assembly And Steal Fxiii A From Native Fxiii A2b2

Background Autoimmune hemophilia‐like disease (hemorrha‐philia or hemorrhagic disorder) caused by anti‐factor XIII antibodies (termed AH13) or 'autoimmune FXIII deficiency' is a life‐threatening bleeding disorder. AH13 was thought to be rare worldwide. Objectives Because the number of diagnosed AH13 cases has recently been increasing, at least in Japan, we conducted a nationwide survey supported by the Japanese Ministry of Health, Labor, and Welfare, and explored the pathologic mechanism(s) of AH13. Methods We diagnosed AH13 cases during the last 11 years according to the presence of anti‐FXIII autoantibodies confirmed by a dot blot assay and ELISA, and characterized 33 of these both immunologically and biochemically. Results The AH13 cases were immunologically classified into three types, Aa, Ab, and B. Type Aa autoantibodies, observed in 27 cases, were directed against the native FXIII A subunit (FXIII‐A), and blocked FXIII activation. The autoantibodies not only prevented assembly of new FXIII‐A2B2 heterotetramers, but also removed FXIII‐A from native FXIII‐A2B2 heterotetramers by forming an FXIII‐A–IgG complex. Type Ab autoantibodies, detected in three cases, preferentially bound to activated FXIII‐A and inhibited its activity. Type Aa and Ab autoantibodies were 'neutralizing' FXIII antibodies (or FXIII inhibitors), and thus could be screened with functional assays. Type B antibodies, detected in two cases, were non‐neutralizing anti‐FXIII B subunit (FXIII‐B) autoantibodies that possibly accelerated the clearance of FXIII, and thus could be diagnosed exclusively with immunologic methods. Conclusion There are three major types of anti‐FXIII autoantibody, with distinct targets and mechanisms that cause AH13.

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