The Pursuit Of Perfection

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Author: Athel Cornish-Bowden
Publisher: Oxford University Press on Demand
ISBN: 9780198520955
Size: 51.31 MB
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The Pursuit Of Perfection by Athel Cornish-Bowden


Original Title: The Pursuit Of Perfection

The term Biochemical Evolution is used to describe the evolution of the biochemical processes and components of living organisms, such as the structure and function of biologically important molecules, metabolic pathways, subcellular structures, and cells. Although a relatively new subject, this field of research has already received great interest from both academia and industry because the principles and theory behind biochemical evolution have enormous potential in the creation and development of new biologically active compounds, drugs, and treatments for disease. However, almost every book that discusses evolution has ignored the role that biochemical evolution plays, and so in his new book, Athel Cornish-Bowden attempts to fill the knowledge gap for students, professional scientists and all interested individuals. In The Pursuit of Perfection the author explains how the biochemical processes that occur in living cells, long thought to be evidence of intelligent design rather than evolution, can now be understood as the result of natural selection. For example, the initial impression that metabolic pathways consist of an almost haphazard collection of reactions that happen to do the job turns out to be quite false. When detailed studies are made to see how the actual organization of a process compares with other ways of achieving the same result, the one found in living organisms is found to be the best possible, or at least very close to it. The style, content and organisation of the book are intended to make the book accessible, interesting, and fun to read for both scientists, students, and scientifically-minded individuals.

Principles Of Enzyme Kinetics

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Author: Athel Cornish-Bowden
Publisher: Elsevier
ISBN: 1483164675
Size: 68.85 MB
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Principles Of Enzyme Kinetics by Athel Cornish-Bowden


Original Title: Principles Of Enzyme Kinetics

Principles of Enzyme Kinetics discusses the principles of enzyme kinetics at an intermediate level. It is primarily written for first-year research students in enzyme kinetics. The book is composed of 10 chapters. Chapter 1 provides the basic principles of enzyme kinetics with a brief discussion of dimensional analysis. Subsequent chapters cover topics on the essential characteristics of steady-state kinetics, temperature dependence, methods for deriving steady-state rate equations, and control of enzyme activity. Integrated rate equations, and introductions to the study of fast reactions and the statistical aspects of enzyme kinetics are provided as well. Chemists and biochemists will find the book invaluable.

Fundamentals Of Enzyme Kinetics

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Author: Athel Cornish-Bowden
Publisher: Elsevier
ISBN: 1483161196
Size: 29.55 MB
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Fundamentals Of Enzyme Kinetics by Athel Cornish-Bowden


Original Title: Fundamentals Of Enzyme Kinetics

Fundamentals of Enzyme Kinetics details the rate of reactions catalyzed by different enzymes and the effects of varying the conditions on them. The book includes the basic principles of chemical kinetics, especially the order of a reaction and its rate constraints. The text also gives an introduction to enzyme kinetics - the idea of an enzyme-substrate complex; the Michaelis-Menten equation; the steady state treatment; and the validity of its assumption. Practical considerations, the derivation of steady-state rate equations, inhibitors and activators, and two-substrate reactions are also explained. Problems after the end of each chapter have also been added, as well as their solutions at the end of the book, to test the readers' learning. The text is highly recommended for undergraduate students in biochemistry who wish to study about enzymes or focus completely on enzymology, as most of the mathematics used in this book, which have been explained in detail to remove most barriers of understanding, is elementary.

Biochemical Evolution The Pursuit Of Perfection 2nd Edition

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Author: Athel Cornish-Bowden
Publisher: Garland Science
ISBN: 1315453169
Size: 23.21 MB
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Biochemical Evolution The Pursuit Of Perfection 2nd Edition by Athel Cornish-Bowden


Original Title: Biochemical Evolution The Pursuit Of Perfection 2nd Edition

Biochemical Evolution: The Pursuit of Perfection, Second Edition describes the relationship between biochemistry and evolutionary biology, arguing that each depends on the other to be properly understood. This relationship is less well known and understood by many biologists, and even by some biochemists, than it ought to be. There are many aspects of evolution that make sense only in the light of biochemical knowledge, just as there are many aspects of biochemistry that make sense only in the light of evolution. It will be an excellent resource for students of evolution, biochemistry, microbiology, and metabolic engineering, and researchers in biology, evolution, biochemistry, genetics, and evolutionary biology. A little knowledge of biochemistry is assumed, and the essential points are summarized in the opening chapter.

Analysis Of Enzyme Kinetic Data

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Author: Athel Cornish-Bowden
Publisher: Oxford University Press, USA
ISBN: 9780198548782
Size: 35.78 MB
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Analysis Of Enzyme Kinetic Data by Athel Cornish-Bowden


Original Title: Analysis Of Enzyme Kinetic Data

This book introduces the theory and practice of statistical analysis of kinetic data for enzyme-catalysed reactions in the steady state. It includes a detailed description of the use of the Leonora program for analysing enzyme kinetic data, together with the program on an IBM PC compatibledisk. Default options and a worked example provide invaluable guidance for the student and the novice and in addition Analysis of Enzyme Kinetic Data provides each reader with the necessary software and the required understanding to tailor an analysis to the requirements of their own research. Theoretical topics include basic principles of a least squares analysis; fitting the Michaelis-Menten equation by a least squares analysis; the general linear model; residual plots; maximum likdlihood and efficiency; generalised medians; and robust regression. Practical topics include examinationand fitting of statistical data; installation of Leonora, its use, simulations, MENUs, and customization.

Basic Mathematics For Biochemists

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Author: A. Cornish-Bowden
Publisher: Springer Science & Business Media
ISBN: 9401165238
Size: 47.81 MB
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Basic Mathematics For Biochemists by A. Cornish-Bowden


Original Title: Basic Mathematics For Biochemists

Some teachers of biochemistry think it positively beneficial for students to struggle with difficult mathematics. I do not number myself among these people, although I have derived much personal pleasure from the study of mathematics and from applying it to problems that interest me in biochemistry. On the contrary, I think that students choose courses in biochemistry out of interest in biochemistry and that they should not be encumbered with more mathematics than is absolutely required for a proper understanding of biochemistry. This of course includes physical chemistry, because a biochemist ignorant of physical chemistry is no biochemist. I have been guided by these beliefs in writing this book. I have laid heavy emphasis on those topics, such as the use of logarithms, that play an important role in biochemistry and often cause problems in teaching; I have ignored others, such as trigonometry, that one can manage without. The proper treatment of statistics has been more difficult to decide. Although it clearly plays an important part in all experi mental sciences, it is usually preferable to treat it as a subject in its own right and not to try to incorporate it into a course of elementary mathematics. In this book, therefore, I have used a few examples from statistics to illustrate more general points, but I have not discussed it for its own sake.

Cin Tique Enzymatique

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Author: Athel Cornish-Bowden
Publisher: EDP Sciences
ISBN: 2759801160
Size: 28.75 MB
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Cin Tique Enzymatique by Athel Cornish-Bowden


Original Title: Cin Tique Enzymatique

Cet ouvrage est l'unique adaptation française du célèbre Fundamentals of Enzyme Kinetics d'Athel Cornish-Bowden. Il donne une description des principes de base des phénomènes d'inhibition et d'activation, de la régulation allostérique et de la coopérativité. Il aborde les systèmes enzymatiques, le contrôle métabolique et en analyse en détail les applications pratiques.

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