Genomic Regulatory Systems

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Author: Eric H. Davidson
Publisher: Elsevier
ISBN: 9780080525594
Size: 32.23 MB
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Genomic Regulatory Systems by Eric H. Davidson

Original Title: Genomic Regulatory Systems

The interaction between biology and evolution has been the subject of great interest in recent years. Because evolution is such a highly debated topic, a biologically oriented discussion will appeal not only to scientists and biologists but also to the interested lay person. This topic will always be a subject of controversy and therefore any breaking information regarding it is of great interest. The author is a recognized expert in the field of developmental biology and has been instrumental in elucidating the relationship between biology and evolution. The study of evolution is of interest to many different kinds of people and Genomic Regulatory Systems: In Development and Evolution is written at a level that is very easy to read and understand even for the nonscientist. * Contents Include * Regulatory Hardwiring: A Brief Overview of the Genomic Control Apparatus and Its Causal Role in Development and Evolution * Inside the Cis-Regulatory Module: Control Logic and How the Regulatory Environment Is Transduced into Spatial Patterns of Gene Expression * Regulation of Direct Cell-Type Specification in Early Development * The Secret of the Bilaterians: Abstract Regulatory Design in Building Adult Body Parts * Changes That Make New Forms: Gene Regulatory Systems and the Evolution of Body Plans

The Regulatory Genome

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Author: Eric H. Davidson
Publisher: Elsevier
ISBN: 9780080455570
Size: 48.42 MB
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The Regulatory Genome by Eric H. Davidson

Original Title: The Regulatory Genome

Gene regulatory networks are the most complex, extensive control systems found in nature. The interaction between biology and evolution has been the subject of great interest in recent years. The author, Eric Davidson, has been instrumental in elucidating this relationship. He is a world renowned scientist and a major contributor to the field of developmental biology. The Regulatory Genome beautifully explains the control of animal development in terms of structure/function relations of inherited regulatory DNA sequence, and the emergent properties of the gene regulatory networks composed of these sequences. New insights into the mechanisms of body plan evolution are derived from considerations of the consequences of change in developmental gene regulatory networks. Examples of crucial evidence underscore each major concept. The clear writing style explains regulatory causality without requiring a sophisticated background in descriptive developmental biology. This unique text supersedes anything currently available in the market. The only book in the market that is solely devoted to the genomic regulatory code for animal development Written at a conceptual level, including many novel synthetic concepts that ultimately simplify understanding Presents a comprehensive treatment of molecular control elements that determine the function of genes Provides a comparative treatment of development, based on principles rather than description of developmental processes Considers the evolutionary processes in terms of the structural properties of gene regulatory networks Includes 42 full-color descriptive figures and diagrams

Genomic Control Process

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Author: Isabelle Peter
Publisher: Academic Press
ISBN: 0124047467
Size: 31.26 MB
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Genomic Control Process by Isabelle Peter

Original Title: Genomic Control Process

Genomic Control Process explores the biological phenomena around genomic regulatory systems that control and shape animal development processes, and which determine the nature of evolutionary processes that affect body plan. Unifying and simplifying the descriptions of development and evolution by focusing on the causality in these processes, it provides a comprehensive method of considering genomic control across diverse biological processes. This book is essential for graduate researchers in genomics, systems biology and molecular biology seeking to understand deep biological processes which regulate the structure of animals during development. Covers a vast area of current biological research to produce a genome oriented regulatory bioscience of animal life Places gene regulation, embryonic and postembryonic development, and evolution of the body plan in a unified conceptual framework Provides the conceptual keys to interpret a broad developmental and evolutionary landscape with precise experimental illustrations drawn from contemporary literature Includes a range of material, from developmental phenomenology to quantitative and logic models, from phylogenetics to the molecular biology of gene regulation, from animal models of all kinds to evidence of every relevant type Demonstrates the causal power of system-level understanding of genomic control process Conceptually organizes a constellation of complex and diverse biological phenomena Investigates fundamental developmental control system logic in diverse circumstances and expresses these in conceptual models Explores mechanistic evolutionary processes, illuminating the evolutionary consequences of developmental control systems as they are encoded in the genome

Systems Biology And Regulatory Genomics

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Author: Eleazar Eskin
Publisher: Springer Science & Business Media
ISBN: 3540482938
Size: 59.45 MB
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Systems Biology And Regulatory Genomics by Eleazar Eskin

Original Title: Systems Biology And Regulatory Genomics

This book constitutes the thoroughly refereed post-proceedings of two joint RECOMB 2005 satellite events: the First Annual Workshop on Systems Biology, RSB 2005 and the Second Annual Workshop on Regulatory Genomics, RRG 2005, held in San Diego, CA, USA in December 2005. It contains 21 revised full papers that address a broad variety of topics in systems biology and regulatory genomics.

Integrating Scientific Disciplines

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Author: William Bechtel
Publisher: Springer Science & Business Media
ISBN: 9401094357
Size: 75.38 MB
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Integrating Scientific Disciplines by William Bechtel

Original Title: Integrating Scientific Disciplines

Interdisciplinary research has been a popular idea with many people in the last 20 years. Academic administrators have admonished their faculty to become more interdisciplinary. Students often request the chance to pursue an interdisciplinary degree. While the issue of managing interdisciplinary projects has received a fair amount of attention by those interested in science management, interdisciplinary research has received little attention from historians, philosophers or sociologists of science or from scientists themselves. Yet, there l;lre a number of cases within the life sciences where researchers have been actively engaged in endeavors that take them across disciplinary boundaries. These are ripe for investigation by those interested in the process of science. To provide an in-depth study of some historical or contemporary cases of cross disciplinary research activity in the life sciences, a conference was held at Georgia State University in May, 1984. This conference was supported by the National Endowment for the Humanities (U. S. A. ) through their research conference program. Over a three-day period historians, philosophers, and researchers who were actively engaged in various of the life sciences discussed specific examples of interdisciplinary research and tried to analyze what was needed for successful crossing of disciplinary boundaries. After the conference, each of the participants revised their original presentations, partly in light of the discussion at the conference. The papers in this volume are the fruits of that endeavor.

Developing Bioinformatics Computer Skills

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Author: Cynthia Gibas
Publisher: "O'Reilly Media, Inc."
ISBN: 9781565926646
Size: 35.44 MB
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Developing Bioinformatics Computer Skills by Cynthia Gibas

Original Title: Developing Bioinformatics Computer Skills

Offers a structured approach to biological data and the computer tools needed to analyze it, covering UNIX, databases, computation, Perl, data mining, data visualization, and tailoring software to suit specific research needs.

Genome Analysis

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Author: Maria S. Poptsova
Publisher: Horizon Scientific Press
ISBN: 1908230290
Size: 69.71 MB
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Genome Analysis by Maria S. Poptsova

Original Title: Genome Analysis

In recent years, there have been tremendous achievements made in DNA sequencing technologies and corresponding innovations in data analysis and bioinformatics that have revolutionized the field of genome analysis. In this book, an impressive array of experts highlight and review current advances in genome analysis. The book provides an invaluable, up-to-date, and comprehensive overview of the methods currently employed for next-generation sequencing (NGS) data analysis. It also highlights their problems and limitations, and it demonstrates the applications and indicates the developing trends in various fields of genome research. The first part of the book is devoted to the methods and applications that arose from, or were significantly advanced by, NGS technologies: the identification of structural variation from DNA-seq data * whole-transcriptome analysis and discovery of small interfering RNAs (siRNAs) from RNA-seq data * motif finding in promoter regions, enhancer prediction, and nucleosome sequence code discovery from ChiP-Seq data * identification of methylation patterns in cancer from MeDIP-seq data * transposon identification in NGS data * metagenomics and metatranscriptomics * NGS of viral communities * causes and consequences of genome instabilities. The second part is devoted to the field of RNA biology, while the final three chapters are devoted to computational methods of RNA structure prediction, including context-free grammar applications.

Development Of The Gastrointestinal Tract

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Author: Ian R. Sanderson
Publisher: PMPH-USA
ISBN: 9781550090819
Size: 59.54 MB
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Development Of The Gastrointestinal Tract by Ian R. Sanderson

Original Title: Development Of The Gastrointestinal Tract

The authors chronicle the development of the gastrointestinal system b eginning with the embryology of the gastrointestinal tract through dev elopment of cells to hormones and enzymes. Each section provides detai led explanation of that stage of development so residents and clinicia ns can better understand the interrelationships of each structure. Spe cial attention is given to the latest cellular information and gene pr omoters in the regulation of intestinal development. Coverage of defec ts due to trauma and infections is also included.

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