Gerd

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Author: Parakrama T. Chandrasoma
Publisher: Academic Press
ISBN: 0128098562
Size: 16.76 MB
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Gerd by Parakrama T. Chandrasoma


Original Title: Gerd

GERD: A New Understanding of Pathology, Pathophysiology, and Treatment transforms the assessment of gastroesophageal reflux disease (GERD) from its present state, which is largely dependent on clinical definition and management, to a more objective scientific basis that depends on pathologic assessment. Sequential chapters in this single-author book describe the fetal development of the esophagus, the normal adult state, and the way exposure to gastric juice causes epithelial and lower esophageal sphincter damage at a cellular level. It allows recognition of the pathologic manifestations of lower esophageal sphincter damage and develops new histopathologic criteria for quantitating such damage. This understanding provides new pathologic criteria for definition and diagnosis of GERD from its earliest cellular stage. Algorithms based on measurement of sphincter damage can identify, even before the onset of clinical GERD, persons who will never develop GERD during life, those who develop GERD but remain with mild and easily controlled disease, and those who will progress to severe GERD with failure to control symptoms, Barrett esophagus and adenocarcinoma. Aggressive early intervention in the last group with the objective of preventing disease progression to its end points of uncontrolled symptoms and adenocarcinoma becomes feasible. Provides a new method of assessment of GERD that has never previously been presented, creating a pathway to control. Describes a new pathologic test based on standard histology that can define lower esophageal sphincter damage. Sequential chapters outline the way GERD progresses from the perspective of the amount of damage to the lower esophageal sphincter. Provides new avenues of clinical research and technologic innovations in pathology and treatment aimed at preventing esophageal adenocarcinoma.

Gerd Reflux To Esophageal Adenocarcinoma

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Author: Parakrama T. Chandrasoma
Publisher: Elsevier Science
ISBN: 9781493300730
Size: 22.25 MB
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Gerd Reflux To Esophageal Adenocarcinoma by Parakrama T. Chandrasoma


Original Title: Gerd Reflux To Esophageal Adenocarcinoma

Gastroesophageal Reflux Disease (GERD) is one of the most common maladies of mankind. Approximately 40% of the adult population of the USA suffers from significant heartburn and the numerous antacids advertised incessantly on national television represents a $8 billion per year drug market. The ability to control acid secretion with the increasingly effective acid-suppressive agents such as the H2 blockers ("pepcid, zantac") and proton pump inhibitors ("nexium, prevacid") has given physicians an excellent method of treating the symptoms of acid reflux. Unfortunately, this has not eradicated reflux disease. It has just changed its nature. While heartburn, ulceration and strictures have become rare, reflux-induced adenocarcinoma of the esophagus is becoming increasingly common. Adenocarcinoma of the esophagus and gastric cardia is now the most rapidly increasing cancer type in the Western world. The increasing incidence of esophageal adenocarcinoma has created an enormous interest and stimulus for research in this area. GERD brings together a vast amount of disparate literature and presents the entire pathogenesis of reflux disease in one place. In addition to providing a new concept of how gastroesophageal reflux causes cellular changes in the esophagus, GERD also offers a complete solution to a problem that has confused physicians for over a century. Both clinical and pathological information about reflux disease and its treatment are presented. GERD is meant to be used as a comprehensive reference for gastroenterologists, esophageal surgeons, and pathologists alike. *Outlines how gastroesophageal reflux causes cellular changes in the esophagus *Brings together the pathogenesis of the disease in one source and applies it toward clinical treatment *Tom DeMeester is THE leading international expert on reflux disease; Parakrama Chandrasoma is one of the leading pathologists in the area *Book contains approximately 350 illustrations *Ancillary web site features color illustrations: www.chandrasoma.com

Shackelford S Surgery Of The Alimentary Tract

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Author: Charles J. Yeo
Publisher: Elsevier Health Sciences
ISBN: 1455738077
Size: 65.26 MB
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Shackelford S Surgery Of The Alimentary Tract by Charles J. Yeo


Original Title: Shackelford S Surgery Of The Alimentary Tract

Comprehensive and complete, Shackelford’s Surgery of the Alimentary Tract delivers the definitive, clinically oriented, cutting-edge guidance you need to achieve optimal outcomes managing the entire spectrum of gastrointestinal disorders. Make effective use of the latest endoscopic, robotic, and minimally invasive procedures as well as medical therapies with unbeatable advice from a "who’s who" of international authorities! Find expert answers to any clinical question in gastrointestinal surgery, from the esophagus to the colon. See exactly what to look for and how to proceed from an abundance of beautifully detailed intraoperative and laparoscopic photographs.

Diagnostic Atlas Of Gastroesophageal Reflux Disease

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Author: Parakrama T. Chandrasoma
Publisher: Academic Press
ISBN: 9780080878034
Size: 60.87 MB
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View: 1978

Diagnostic Atlas Of Gastroesophageal Reflux Disease by Parakrama T. Chandrasoma


Original Title: Diagnostic Atlas Of Gastroesophageal Reflux Disease

Gastroesophageal reflux is one of the most common maladies of mankind. Approximately 40% of the adult population of the USA suffers from significant heartburn and the numerous antacids advertised incessantly on national television represents a $8 billion per year drug market. The ability to control acid secretion with the increasingly effective acid-suppressive agents such as the H2 blockers (pepcid, zantac) and proton pump inhibitors (nexium, prevacid) has given physicians an excellent method of treating the symptoms of acid reflux. Unfortunately, this has not eradicated reflux disease. It has just changed its nature. While heartburn, ulceration and strictures have become rare, reflux-induced adenocarcinoma of the esophagus is becoming increasingly common. Adenocarcinoma of the esophagus and gastric cardia is now the most rapidly increasing cancer type in the Western world. At present, there is no histologic test that has any practical value in the diagnosis of reflux disease. The only histologic diagnostic criteria are related to changes in the squamous epithelium which are too insensitive and nonspecific for effective patient management. It is widely recognized that columnar metaplasia of the esophagus (manifest histologically as cardiac, oxyntocardiac and intestinal epithelia) is caused by reflux. However, except for intestinal metaplasia, which is diagnostic for Barrett esophagus, these columnar epithelia are not used to diagnose reflux disease in biopsies. The reason for this is that these epithelial types are indistinguishable from "normal" "gastric" cardiac mucosa. In standard histology texts, this "normal gastric cardia" is 2-3 cm long. In the mid-1990s, Dr. Chandrasoma and his team at USC produced autopsy data suggesting that cardiac and oxyntocardiac mucosa is normally absent from this region and that their presence in biopsies was histologic evidence of reflux disease. From this data, they determined that the presence of cardiac mucosa was a pathologic entity caused by reflux and could therefore be used as a highly specific and sensitive diagnostic criterion for the histologic diagnosis of reflux disease. They call this entity "reflux carditis". In addition, the length of these metaplastic columnar epithelia in the esophagus was an accurate measure of the severity of reflux disease in a given patient. At present, there is some controversy over whether cardiac mucosa is totally absent or present normally to the extent of 0-4 mm. While this should not be a deterrent to changing criteria which are dependent on there normally being 20-30 cm of cardiac mucosa, there has been little mainstream attempt to change existing endoscopic and pathologic diagnostic criteria in the mainstream of either gastroenterology or pathology. The ATLAS will be the source of easily digestible practical information for pathologists faced with biopsies from this region. It will also guide gastroenterologists as they biopsy these patients. The American Gastroenterological Association claims there are 14,500 members worldwide who are practicing physicians and scientists who research, diagnose and treat disorders of the gastrointestinal tract and liver According to the American Society for Clinical Pathology, there are 12,000 board certified pathologists in the U.S. Adenocarcinoma of the esophagus and gastric cardia is now the most rapidly increasing cancer type in the Western world Approximately 40% of the adult population of the U.S. suffers from significant heartburn and the numerous antacids advertised on national television represents an $8 billion per year drug market

Esophagitis New Insights For The Healthcare Professional 2012 Edition

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Author:
Publisher: ScholarlyEditions
ISBN: 1464985367
Size: 44.17 MB
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Esophagitis New Insights For The Healthcare Professional 2012 Edition by


Original Title: Esophagitis New Insights For The Healthcare Professional 2012 Edition

Esophagitis: New Insights for the Healthcare Professional / 2012 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Esophagitis in a compact format. The editors have built Esophagitis: New Insights for the Healthcare Professional / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Esophagitis in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Esophagitis: New Insights for the Healthcare Professional / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Sleisenger And Fordtran S Gastrointestinal And Liver Disease

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Author: Mark Feldman
Publisher: Elsevier Health Sciences
ISBN: 1437727670
Size: 72.64 MB
Format: PDF
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Sleisenger And Fordtran S Gastrointestinal And Liver Disease by Mark Feldman


Original Title: Sleisenger And Fordtran S Gastrointestinal And Liver Disease

Make optimal use of the newest techniques, technologies, and treatments with Sleisenger and Fordtran's Gastrointestinal and Liver Disease - the indispensable information source in this broad field! Edited by Mark Feldman, MD, Lawrence S. Friedman, MD, and Lawrence J. Brandt, MD, this 9th Edition equips you with the amassed knowledge of hundreds of respected authorities from around the world, helping you to overcome all of your most complex clinical challenges and make the most effective use of the newest techniques, technologies, and treatments. Significant updates on bariatric surgery, Barrett's esophagus, and many other evolving areas keep your practice current. Full-text online access includes downloadable illustrations and links to reference abstracts. The result remains the indispensable core reference in gastroenterology and hepatology. World-renowned experts provide reliable guidance on every area of your field. A consistent, full-color chapter design lets you find information quickly. Significant updates on bariatric surgery, Barrett's esophagus, endoscopic ultrasound, endosonography, treatment of liver disease, and much more keep you current on the latest advances. Many new contributors from all over the world provide you with fresh insights on all areas of gastroenterology and hepatology. Full-text online access via Expert Consult includes downloadable illustrations and links to reference abstracts.

Laparoscopic Surgery

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Author: Ronald C. Merrell
Publisher: Springer Science & Business Media
ISBN: 1461214084
Size: 65.24 MB
Format: PDF
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Laparoscopic Surgery by Ronald C. Merrell


Original Title: Laparoscopic Surgery

In May 1997 the Faculty of Surgery from the University of Athens and elsewhere gathered with colleagues in Athens for the third time in 6 years to continue our discussions on the progress, problems, realization, and future of laproscopic surgery. The topics were rather inclusive with regard to the issues that defined the field, and the assembled investigators, educa tors, and clinicians brought a rich experience and clear vision of the field in the coming years. The decision had been made months before to collect our thoughts and experience as a colloquium of the state of laproscopic surgery in the tenth year following the report of Mouret on laparoscopic cholecy stectomy, not as the proceedings of the specific meeting. At the end of a decade of mercurial advance, heated debate, professional turmoil, and very little science, it was clear that general surgery would never be the same. Laproscopic surgery is now fully established and requires accommodation in the curriculum, practice, and research of surgery for the foreseeable future. This book is called a colloquium on laparoscopy because it collects the thoughts of many workers in the form of consensus presentations. It is offered to any surgeon who is ready to survey this field with clear eyes, absent of emotion or hyperbole, in our evolution of a better standard of care for surgical patients.

Gastroesophageal Reflux Disease

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Author: Roy C. Orlando
Publisher: CRC Press
ISBN: 0203909852
Size: 32.38 MB
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Gastroesophageal Reflux Disease by Roy C. Orlando


Original Title: Gastroesophageal Reflux Disease

This detailed monograph encompasses the epidemiology, pathogenesis, diagnosis, management, and complications of gastroesophageal reflux disease (GERD). With coverage unparalleled elsewhere, Gastroesophageal Reflux Disease concentrates on various disorders sharing the common pathogenesis of gastroesophageal reflux, including disorders of the esophagus, oropharynx, larynx, and upper respiratory tract. This indispensable reference compares GERD's pathogenesis from traditional (motor) and atraditional (epithelial) approaches profiles asymmetric conditions in children and adults highlights precursors of esophageal adenocarcinoma explains the mechanisms of how acid damages the esophageal epithelium illustrates GERD's relationship to extra-esophageal conditions such as laryngitis, chronic bronchitis, and asthma and more! Written by internationally recognized specialists and supplemented with over 1200 literature references, drawings, photographs, X-rays, and tables, Gastroesophageal Reflux Disease is a necessary addition to the library of gastroenterologists, internists, general and thoracic surgeons, family practitioners, pediatricians, surgical and medical residents, pharmacists and pharmacologists, pulmonologists, otolarynogologists, oncologists, pathologists, and graduate and medical school students in these disciplines.

Advancing Medicine With Food And Nutrients Second Edition

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Author: Ingrid Kohlstadt
Publisher: CRC Press
ISBN: 1439887721
Size: 24.61 MB
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Advancing Medicine With Food And Nutrients Second Edition by Ingrid Kohlstadt


Original Title: Advancing Medicine With Food And Nutrients Second Edition

Food and nutrients are the original medicine and the shoulders on which modern medicine stands. But in recent decades, food and medicine have taken divergent paths and the natural healing properties of food have been diminished in the wake of modern technical progress. With contributions from highly regarded experts who work on the frontlines of disease management, the bestselling first edition of Advancing Medicine with Food and Nutrients, Food and Nutrients in Disease Management effectively brought food back into the clinical arena, helping physicians put food and nutrients back on the prescription pad. Board-certified in General Preventive Medicine, Ingrid Kohlstadt, MD, MPH has been elected a Fellow of the American College of Nutrition and a Fellow of the American College of Preventive Medicine. Guided by Dr. Kohlstadt, this authoritative reference equips clinicians with the information they need to fully utilize nutritional medicine in their practice. New in the Second Edition Toxic exposures such as molds, microbial infections, xenoestrogens, heavy metals, and inert nanoparticles Food safety issues: precautions for patients with preexisting medical conditions, adequate labeling of food allergens such as gluten, potential adverse effects of artificial sweeteners, consequences of applying ionizing radiation to food, food-borne mycotoxins, critical food restrictions following bariatric surgery, precautions for preparing food in the home Consumer advocacy issues on navigating claims of medical foods and dietary supplements Physical forces on nutritional needs, such as ultraviolet light initiating vitamin D synthesis, non-ionizing radiation’s effects on brain glucose metabolism and excess body fat’s effects on inflammation and hydration Preventive medicine and how to preserve resiliency at the individual and public health levels Written by doctors for doctors, Advancing Medicine with Food and Nutrients, Second Edition reunites food and medicine. Buttressed with new evidence, leading physicians on the frontlines of disease management apply the latest scientific advances to the clinical practice of medicine. Each chapter offers adjuncts to standard care, fewer side effects, improved risk reduction, or added quality of life. An article by Ingrid Kohlstadt on education and nutrition appeared in TIME Magazine online on November 12, 2014.

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