Human Brain Proteome

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Publisher: Elsevier
ISBN: 9780080522463
Size: 57.82 MB
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Human Brain Proteome by

Original Title: Human Brain Proteome

Proteomics is a systematic approach for studying the identity and function of all proteins expressed in a cell, tissue or organ. New drug targets for diseases are often identified by comparing the proteome of the disease state to the normal state. As a result, proteomics has become increasingly important in the pharmaceutical and biotechnology industries as well as academics. This book contains five sections encompassing the research aspects of proteomics on the brain including the most recent advances in the technology and informatics. It discusses advances in high-throughput proteomic technologies and their application to studying neurological disorders such as Alzheimer’s disease, alcoholism, trauma/stroke, Huntington's disease, and Parkinson's disease. With numerous illustrations to explain the concepts, it provides a comprehensive review on the topic. * Describes the latest databases and techniques for analyzing the data generated by proteomics * Outlines the latest developments in proteomic methods * Provides numerous color illustrations highlighting the application of proteomics to the identification of novel drug targets and biomarkers

Proteomics In Drug Research

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Author: Michael Hamacher
Publisher: John Wiley & Sons
ISBN: 9783527312269
Size: 47.22 MB
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Proteomics In Drug Research by Michael Hamacher

Original Title: Proteomics In Drug Research

From skillful handling of the wide range of technologies to successful applications in drug discovery—this handbook has all the information professional proteomics users need. Edited by experts working at one of the hot spots in European proteomic research, the numerous contributions by experts from the pharmaceutical industry and public proteomics consortia to provide the necessary perspective on current trends and developments in this exciting field. Following an introductory chapter, the book moves on to proteomic technologies, such as protein biochips, protein-protein interactions, and proteome analysis in situ. The section on applications includes bioinformatics, Alzheimer's disease, neuroproteomics, plasma and T-cell proteomics, differential phosphoproteome analysis and biomarkers, as well as pharmacogenomics. Invaluable reading for medicinal and pharmaceutical chemists, gene technologists, molecular biologists, and those working in the pharmaceutical industry.

Functional Genomics And Proteomics In The Clinical Neurosciences

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Author: Scott E. Hemby
Publisher: Elsevier
ISBN: 9780080465630
Size: 63.36 MB
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Functional Genomics And Proteomics In The Clinical Neurosciences by Scott E. Hemby

Original Title: Functional Genomics And Proteomics In The Clinical Neurosciences

The purpose of this work is to familiarize neuroscientists with the available tools for proteome research and their relative abilities and limitations. To know the identities of the thousands of different proteins in a cell, and the modifications to these proteins, along with how the amounts of both of these change in different conditions would revolutionize biology and medicine. While important strides are being made towards achieving the goal of global mRNA analysis, mRNA is not the functional endpoint of gene expression and mRNA expression may not directly equate with protein expression. There are many potential applications for proteomics in neuroscience: determination of the neuro-proteome, comparative protein expression profiling, post-translational protein modification profiling and mapping protein-protein interactions, to name but a few. Functional Genomics and Proteomics in Clinical Neuroscience will comment on all of these applications, but with an emphasis on protein expression profiling. This book combines the basic methodology of genomics and proteomics with the current applications of such technologies in understanding psychiatric illnesses. * Introduction of basic methodologies in genomics and proteomics and their integration in psychiatry * Development of the text in sections related to methods, application and future directions of these rapidly advancing technologies * Use of actual data to illustrate many principles of functional genomics and proteomics. * Introduction to bioinformatics and database management techniques

Proteome Analysis

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Author: David W. Speicher
Publisher: Elsevier
ISBN: 9780444510242
Size: 34.94 MB
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Proteome Analysis by David W. Speicher

Original Title: Proteome Analysis

State-of-the-art protein profiling methods include high resolution two-dimensional gels, two-dimensional differential in-gel electrophoresis, LC-MS and LC-MS/MS using accurate mass tags, and protein identifications of proteins from gels using mass spectrometry methods are discussed in depth. Other chapters describe comprehensive characterization of proteomes using electrophoretic prefractionation and analyses of sub-proteomes based on specific posttranslational modifications including the phospho-proteome, the glyco-proteome, and nitrated proteins. These conventional proteome analysis chapters are complemented by discussion of emerging technologies and approaches such as affinity based biosensor proteomics as well as the use of protein microarrays, microfluidics and nanotechnology. Strategies for improving throughput by automation are also discussed.-

Subcellular Proteomics

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Author: Eric Bertrand
Publisher: Springer Science & Business Media
ISBN: 1402059434
Size: 79.60 MB
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Subcellular Proteomics by Eric Bertrand

Original Title: Subcellular Proteomics

This volume summarizes the new developments that made subcellular proteomics a rapidly expanding area. It examines the different levels of subcellular organization and their specific methodologies. In addition, the book includes coverage of systems biology that deals with the integration of the data derived from these different levels to produce a synthetic description of the cell as a system.

Schizophrenia New Insights For The Healthcare Professional 2011 Edition

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Publisher: ScholarlyEditions
ISBN: 1464900183
Size: 10.59 MB
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Schizophrenia New Insights For The Healthcare Professional 2011 Edition by

Original Title: Schizophrenia New Insights For The Healthcare Professional 2011 Edition

Schizophrenia: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Schizophrenia. The editors have built Schizophrenia: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Schizophrenia in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Schizophrenia: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at

The Omics

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Author: Giovanni Coppola
Publisher: Oxford University Press
ISBN: 0199355002
Size: 53.42 MB
Format: PDF
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The Omics by Giovanni Coppola

Original Title: The Omics

The OMICs: Applications in Neuroscience summarizes the state of the art in high-throughput approaches (collectively known as 'OMICs') in neurology and neuroscience, and is of interest to both neurologists tracking the progress of these methods towards clinical applications, and neuroscientists curious about the most recent advances in this ever-changing field. The explosion of high-throughput assays has introduced large datasets, computational servers, and bioinformatics approaches to neuroscience, and medicine in general. The book includes a rich survey of the most relevant OMICs applications and how they relate to neurology and neuroscience. The reader is given an overview of the method, a perspective on the current and future applications, and published examples illustrating practical uses.

Exploring The Human Plasma Proteome

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Author: Gilbert S. Omenn
Publisher: John Wiley & Sons
ISBN: 3527609423
Size: 67.98 MB
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Exploring The Human Plasma Proteome by Gilbert S. Omenn

Original Title: Exploring The Human Plasma Proteome

On the cutting edge of medical diagnostics, plasma proteomics promises to generate a new wave of technologies to help identify many different diseases and disease risks. Plasma and serum are the preferred non-invasive specimens to test normal individuals, at-risk groups, and patients for protein biomarkers discovered and validated to reflect physiological, pathological, and pharmacological phenotypes. These specimens present enormous challenges due to extreme complexity, huge dynamic range in protein concentrations, non-standardized methods of sample processing, and intra- and inter-individual variation from genetics, diet, smoking, hormones, and other sources. This book presents the major findings from the collaborative Plasma Proteome Project organized by the international Human Proteome Organization (HUPO). The chapters are drawn from a larger set of publications in the journal PROTEOMICS. This book provides a valuable foundation for development and applications of proteomics.

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