Immunopotentiators In Modern Vaccines

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Author: Virgil Schijns
Publisher: Academic Press
ISBN: 0128040955
Size: 27.32 MB
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Immunopotentiators In Modern Vaccines by Virgil Schijns

Original Title: Immunopotentiators In Modern Vaccines

Immunopotentiators in Modern Vaccines, Second Edition, provides in-depth insights and overviews of the most successful adjuvants, those that have been included in licensed products, also covering the most promising technologies that have emerged in recent years. In contrast to existing books on the subject, the chapters here provide summaries of key data on the mechanisms of action of the individual vaccine adjuvants. In addition, the book covers key aspects of how the technologies might be further developed and what might be their limitations, while also giving an overview of what made the most advanced adjuvant technologies successful. Provides contributions from leading international authorities in the field Features immunopotentiators classified by function, with well-illustrated, informative figures presenting the interaction between the immunopotentiators and the host immune system Lists advantages and potential hurdles for achieving a practical application for each specific immunopotentiator Offers US FDA perspectives which highlight how future adjuvants will be approved for new generation vaccines

Subunit Vaccine Delivery

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Author: Camilla Foged
Publisher: Springer
ISBN: 1493914170
Size: 19.58 MB
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Subunit Vaccine Delivery by Camilla Foged

Original Title: Subunit Vaccine Delivery

This comprehensive volume compiles the concepts essential for the understanding of the pharmaceutical science and technology associated with the delivery of subunit vaccines. Twenty-one chapters are divided into four main parts: (I) Background; (2) Delivery Systems for Subunit Vaccines; (3) Delivery Routes, Devices and Dosage Forms; and (4) Pharmaceutical Analysis and Quality Control of Vaccines. Part one provide a basic background with respect to immunology and general vaccine classification. In part two, it presents representative types of vaccine delivery systems individually with focus on the physicochemical properties of the systems and their significance for the immune response they stimulate. These delivery systems include aluminum adjuvants, emulsions, liposomes, bilosomes, cubosomes/hexosomes, ISCOMs, virus-like particles, polymeric nano- and microparticles, gels, implants and cell-based delivery systems. Following these chapters, part three addresses the challenges associated with vaccine delivery via specific routes of administration—in particular subcutaneous, intramuscular, oral, nasal, pulmonary, transdermal and vaginal administration. Furthermore, the specific administration routes are discussed in combination with device technologies relevant for the respective routes as well as dosage forms appropriate for the device technology. Finally, the fourth part concerns pharmaceutical analysis and quality control of subunit vaccines.

Rede Nanobiotec

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Size: 52.85 MB
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Rede Nanobiotec by 1. BRAZILIAN WINTER SCHOOL ON NANOBIOTECHNOLOGY (2002, [Sao Carlos].)

Original Title: Rede Nanobiotec

The brazilian initiative in nanoscience and nanotechnology; Basic knowledge and preparation of liposomes; Chemical and physico-chemical characterization of liposomes; Liposomes: progress and problems; Biodegradable polymers; Applications of lectins in pharmaceutical nanotechnology; Microtechnologies for the delivery of bioactive copound; Biosynthetic apolyhydroxyalkanoates and their potential in drug delivery; Preparation of Magnetic fluids based on ferric oxides; Physical characterization of magnetic nanoparticles usind dinamic susceptibility and magnetic resonance: an overview; The combination of atomic force microscopy (AFM) and laser-based microdissection as a isolation tool for cytogenetics; Applications of near field scanning optical microscopy; Image treatment in atomic force microscopy; AFM force spectroscopy; Chemical force microscopy for surface characterization; Nanostructured films of conductive polymers for sensor applications; Solid state NMR in protein structure; Patents & technology transfer at FAPESP; Comparative studies of drug transport by nano and microparticles; In vitro toxicological assays of nanoparticulate systems,; Particles for gene therapy; Pharmacokinetics and pharmacodinamics of nanoparticulate systems; DNA delivery systems; Purification and refolding of ifn alpha 8 expressed in E. coli; Particulate immunopotentiators for modern vaccines; Clinical trials of veterinary products: regulatory issues; Radioactive microspheres for cancer therapyi; Photodynamic therapy and fluid liposomes; Transdermic systems; Nasal and pulmonar administration of nanoparticulate systems; granules of nanocapsules srpay-dried powders prepared from suspensions obtained by nanoprecipitation of emulsification diffusion technique: development and characterization; Encapsulation of bauhinia monandra lectin (BmoLL) in new dextran-PCL nanoparticles; Oral lyofilisates obtained from diclofenac-loaded polymeric nanocapsules. preparation, morphologic characterization and gastrointestinal tolerance evaluation; Comparison between microdialysis and ultrafiltration/centrifugation as technique to evaluate the association of a lipophilic drug to nanoparticles; Preparation of alginate-chitosan microparticles; Nanocoated microparticles: a new technological strategy to obtain modified drug release systems; Indomethacin ethyl ester associated with nanocapsules, nanospheres and nanoemulsion: a comparative study; Preparation of 17-beta-estradiol-loaded pla microparticles by emulsion/evaporation method; Development of biodegradable microcapsules for administration of medicines; Study of incorporation of praziquantel into phosphatidylcholine-containing liposomes to improve the antischistosomal activity; Electron paramagnetic resonance of nitroxide-doped magnetic fluids; Application of finite element method to biotechnology; Characterization of carbamazepine microspheres prepared from cellulose acetate butirate and polyethylene glycol blends; Self-assembled thin films containing cytochrome C and A 1,4,5,8-Naphthalenediimide; Cubic liqud crystalline nanoparticles as drug delivery systems: obtainment and characterization; Functionalization protocols for atomic force spectroscopy; Bilayer liposome model to study the effects of reactive oxygen species on cell membranes; Characterization of lysozyme self-assembly film by UV; Redox activity of immobilized proteins; Nanostructured lipid-free formulation of amphotericin; Paracetamol permeation through cellulose acetate blends: plasticizing effect; Purification of the beta toxin of Clostridium perfingens and evaluaton of its biological activity in vivo; Biodistribution of antimony in dogs following the intravenous administration of meglumine antimonate encapsulated in freze-dried empty liposomes; Preparation, characterization and in vivo assays of liposomes and microspheres (PLGA) useful for desensitization therapy in allergy; Micro-and nanospheres of poly(e-caprolactone) in the anti-cancer, anti-tuberculosis and anti-ulcer drugs encapsulation; Cytoxicity of e-polycaprolactone nanospheres incorporating dehydrocrotonin on leukemic cells.

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