Long Noncoding Rnas

Download Read Online Long Noncoding Rnas book
Author: Riki Kurokawa
Publisher: Springer
ISBN: 4431555765
Size: 29.95 MB
Format: PDF, Mobi
View: 3577

Long Noncoding Rnas by Riki Kurokawa


Original Title: Long Noncoding Rnas

This book presents a common principle of actions of long noncoding RNAs (lncRNAs) from points of view at the atomic, molecular and cellular levels. At the atomic level, chemical studies of ribonucleic acids explain the chemical behavior of lncRNAs. Structural biological analysis of lncRNAs and its binding proteins also reveal the precise mechanisms of their actions. Molecular biological approaches lead to insights into molecular mechanisms of these lncRNA actions. At the cellular or individual level of analysis, we grasp the biology and medicine of lncRNAs. These three layers of approaches are thoroughly new and produce novel insights into functions of lncRNAs in living cells. The book consists of five parts: 1) Bioinformatics and other methodologies for lncRNAs, 2) Atomic and molecular structures of lncRNAs, 3) Molecular functions of lncRNAs, 4) Biological actions of lncRNAs, and 5) Potential outcomes for clinical medicine. These sections connect well and work synergistically. The book is for researchers whose specialty is RNA biology and chemistry and also for advanced students at the graduate and undergraduate levels. Readers can grasp the leading edge of lncRNA studies in a comprehensive manner and are inspired to pursue their own particular interests.

Molecular Biology Of Long Non Coding Rnas

Download Read Online Molecular Biology Of Long Non Coding Rnas book
Author: Ahmad M. Khalil
Publisher: Springer Science & Business Media
ISBN: 1461486211
Size: 72.76 MB
Format: PDF
View: 975

Molecular Biology Of Long Non Coding Rnas by Ahmad M. Khalil


Original Title: Molecular Biology Of Long Non Coding Rnas

​Long non-coding RNAs (lnc)RNAs have emerged as a new paradigm in epigenetic regulation of the genome. Thousands of lncRNAs have been identified and observed in a wide range of organisms. Unlike mRNA, lncRNA have no protein-coding capacity. ​So, while their function is not entirely clear, they may serve as key organizers of protein complexes that allow for higher order regulatory events. Discovering these functions has been the result of intense research done of the last few years, and lncRNA research has had several critical developments during that time. This book will consolidate these ideas and models to better examine the most important issues in lncRNA biology. This will include critical studies that have led to the discovery and annotation of lncRNAs in numerous species, and the molecular mechanisms for a few lncRNA that have begun to emerge.

Long Non Coding Rnas In Human Disease

Download Read Online Long Non Coding Rnas In Human Disease book
Author: Kevin V. Morris
Publisher: Springer
ISBN: 3319239074
Size: 60.24 MB
Format: PDF, Mobi
View: 1875

Long Non Coding Rnas In Human Disease by Kevin V. Morris


Original Title: Long Non Coding Rnas In Human Disease

This volume focuses on the roles of long non-coding RNAs (lncRNAs) in contexts ranging from human cancers to cardiovascular disease and ageing. The role of lncRNAs in X-inactivation and those lncRNAs derived from pseudogenes, past retroelements integrated within the human genome, as well as the role these pseudogene-derived lncRNAs play in cancer development are discussed in detail. Further, the book examines the function of lncRNAs in diseases such as diabetes, in smooth muscle formation, and in the modulation of nuclear receptors, as well as in connection with perspectives on the development of personalized therapeutics. It offers an appealing and insightful resource for scientists and clinicians alike.

Long Non Coding Rna Biology

Download Read Online Long Non Coding Rna Biology book
Author: M.R.S. Rao
Publisher: Springer
ISBN: 9811052034
Size: 79.63 MB
Format: PDF, ePub, Docs
View: 2548

Long Non Coding Rna Biology by M.R.S. Rao


Original Title: Long Non Coding Rna Biology

This contributed volume offers a comprehensive and detailed overview of the various aspects of long non-coding RNAs and discusses their emerging significance. Written by leading experts in the field, it motivates young researchers around the globe, and offers graduate and postgraduate students fascinating insights into genes and their regulation in eukaryotes and higher organisms.

Long Non Coding Rnas

Download Read Online Long Non Coding Rnas book
Author: Ðurðica Ugarković
Publisher: Springer Science & Business Media
ISBN: 9783642165023
Size: 20.21 MB
Format: PDF, ePub, Mobi
View: 1366

Long Non Coding Rnas by Ðurðica Ugarković


Original Title: Long Non Coding Rnas

Long non-coding RNAs (lncRNAs), tentatively defined as ncRNAs of more than two hundred nucleotides in length, are characterized by the complexity and diversity of their sequences and mechanisms of action. Based on genome-wide studies, more than 3,300 of them exist, but to date only the limited number of functional lncRNAs have been identified and characterized. Nonetheless, lncRNAs have emerged as key molecules involved in the control of transcriptional and posttranscriptional gene regulatory pathways. They take part in the recruitment of chromatin modifying complexes and regulate splicing, localization, stability and translation of the target mRNAs. This book provides an overview of the rapidly advancing field of long ncRNAs, describing the epigenetic and non-epigenetic mechanisms by which they regulate various biological functions in model systems, from yeast to mammals. The role of ncRNAs in sex chromosome dosage compensation in flies and mammals is described, as well as their role in centromere and telomere biology. Long non-coding RNAs involved in environmental stress response and development are presented and their mechanisms of action discussed.

Long Noncoding Rnas

Download Read Online Long Noncoding Rnas book
Author: Vinod Scaria
Publisher: Academic Press
ISBN: 0128042478
Size: 60.40 MB
Format: PDF, Docs
View: 3346

Long Noncoding Rnas by Vinod Scaria


Original Title: Long Noncoding Rnas

Long Noncoding RNAs: Basic Science to Disease Biology provides an overview of the state-of-the-art methods in the field that have created an understanding of the sequence, structure, function and disease associations of lncRNAs. The decade following the availability of the reference human genome has seen tremendous advancements in the scale and throughput of nucleotide sequencing and its widespread application. This sequencing technology has allowed for rapid, advanced study of the functionalities of lncRNAs and has revealed their intricate and important roles in a variety of biological processes and pathophysiology of diseases. Features approaches to characterize the function of lncRNA Presents information on high-throughput functional screening and imaging Includes a chapter on RNA-Capture Seq for the annotation of lncRNAs

Long Non Coding Rnas

Download Read Online Long Non Coding Rnas book
Author: Yi Feng
Publisher: Humana Press
ISBN: 9781493933761
Size: 48.54 MB
Format: PDF, ePub, Docs
View: 7240

Long Non Coding Rnas by Yi Feng


Original Title: Long Non Coding Rnas

This volume assembles a broad spectrum of methods used in long non-coding RNAs (lncRNA) research, ranging from computational annotation of lncRNA genes to molecular and cellular analyses of the function of individual lncRNA. Long Non-Coding RNAs: Methods and Protocols also discusses methods used to study circular RNAs and RNA splicing, as well as influential findings on lncRNA in human diseases. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and cutting-edge, Long Non-Coding RNAs: Methods and Protocols is a must-have for molecular biologists, cell and developmental biologists, specialists who conduct disease-oriented research, and bioinformatics experts who seek a better understanding on lncRNA expression and function by computational analysis of the massive sequencing data that are rapidly accumulating in recent years.

Emerging Roles Of Long Noncoding Rnas In Neurological Diseases And Metabolic Disorders

Download Read Online Emerging Roles Of Long Noncoding Rnas In Neurological Diseases And Metabolic Disorders book
Author: Yingqun Huang
Publisher: Frontiers Media SA
ISBN: 2889195716
Size: 63.17 MB
Format: PDF
View: 276

Emerging Roles Of Long Noncoding Rnas In Neurological Diseases And Metabolic Disorders by Yingqun Huang


Original Title: Emerging Roles Of Long Noncoding Rnas In Neurological Diseases And Metabolic Disorders

Long noncoding RNAs (lncRNAs) are a new class of transcripts that are in general longer than 200 nucleotides and that have no protein-coding potential. The vast majority of vertebrate genomes encode diverse and complex lncRNAs that play regulatory roles at almost every step of gene expression. Recently, increasing evidence has implicated lncRNAs in the pathogenesis of various human diseases. The purpose of the Research Topic, "Emerging roles of long noncoding RNAs in neurological diseases and metabolic disorders", is to bring together leading researchers in the field who, through contributing to an organized and comprehensive collection of peer-reviewed articles, provide a broad perspective on the latest advances in the field. A number of interesting and cutting-edge areas will be covered as below, but this list is not exclusive: - The methodologies and technologies of identifying and studying lncRNAs - LncRNAs in gene-specific transcription - LncRNAs in epigenetic regulation - LncRNAs in post-transcriptional regulation - LncRNAs in disease - Mapping of noncoding single nucleotide polymorphisms associated with disease.

Cancer And Noncoding Rnas

Download Read Online Cancer And Noncoding Rnas book
Author: Jayprokas Chakrabarti
Publisher: Academic Press
ISBN: 0128134372
Size: 12.46 MB
Format: PDF, ePub, Docs
View: 5128

Cancer And Noncoding Rnas by Jayprokas Chakrabarti


Original Title: Cancer And Noncoding Rnas

Cancer and Noncoding RNAs offers an in-depth exploration of noncoding RNAs and their role in epigenetic regulation of complex human disease, most notably cancer. In addition to examining microRNAs, this volume provides a unique evaluation of more recently profiled noncoding RNAs now implicated in carcinogenesis, including lncRNAs, piRNAs, circRNAs, and tRNAs, identifying differences in function between these noncoding RNAs and how they interact with the rest of the epigenome. A broad range of chapters from experts in the field detail epigenetic regulation of various cancer types, along with recent next generation sequencing technologies, genome-wide association studies (GWAS) and bioinformatics approaches. This book will help researchers in genomic medicine and cancer biology better understand the role of noncoding RNAs in epigenetics, aiding in the development of useful biomarkers for diagnosis, prognosis and new RNA-based disease therapies. Provides a comprehensive analysis of noncoding RNAs implicated in epigenetic regulation of gene expression and chromatin dynamics Educates researchers and graduate students by highlighting, in addition to miRNAs, a range of noncoding RNAs newly associated with carcinogenesis Applies current knowledge of noncoding RNAs and epigenomics towards developing cancer and RNA-based disease therapies Features contributions by leading experts in the field

Genome Regulation By Long Noncoding Rnas

Download Read Online Genome Regulation By Long Noncoding Rnas book
Author: Jesse Michael Engreitz
Publisher:
ISBN:
Size: 74.29 MB
Format: PDF, ePub, Mobi
View: 2050

Genome Regulation By Long Noncoding Rnas by Jesse Michael Engreitz


Original Title: Genome Regulation By Long Noncoding Rnas

Our genomes encode the molecular information that gives rise to life, yet we are just beginning to unravel how this information is organized, interpreted, and regulated. While the human genome contains -20,000 protein-coding genes, mammalian genomes also produce thousands of long non-coding RNAs (lncRNAs), some of which are now known to play essential roles in diverse biological processes including cellular differentiation and human disease. Recent studies show that many lncRNAs localize to the nucleus and interact with chromatin regulatory complexes, suggesting that some lncRNAs may represent a crucial missing component in our understanding of genome regulation. To test whether lncRNAs localize to and regulate specific sites in the genome, we developed genome-wide approaches to map lncRNA interactions with chromatin. Through studies of three conserved lncRNAs, we demonstrate that lncRNAs can exploit the three-dimensional architecture of the genome to identify their regulatory targets and, in turn, actively manipulate genome architecture to form subcompartments containing co-regulated genes. Thus, lncRNAs have unique capabilities as dynamic regulators that can locally amplify epigenetic signals. We next explored whether this model might apply to other long noncoding RNAs, many of which are not conserved across species and thus whose functions remain unclear. Through genetic dissection of their local regulatory functions, we show that many of these genomic loci participate in the local regulation of gene expression, but that these functions do not involve the IncRNA transcripts themselves. Instead, multiple mechanisms associated with RNA production including their promoters, the process of transcription, and RNA splicing - act in local networks of regulatory connections between spatially proximal genes, both protein-coding and noncoding. These findings reveal novel mechanistic explanations for the functions and evolution of noncoding transcription in mammalian genomes. Together these studies suggest a model in which mammalian gene regulation is organized into local neighborhoods defined by the spatial architecture of the genome. Within these neighborhoods, lncRNAs and DNA regulatory elements may function cooperatively to coordinate local gene expression. Dissecting this fundamental model for genome regulation may enable manipulation of the processes that interpret our genome sequence and galvanize efforts to develop new treatments for human disease.

Recent Books :