Monoclonal Antibodies

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Author: James W. Goding
Publisher: Elsevier
ISBN: 9780080536958
Size: 64.89 MB
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Monoclonal Antibodies by James W. Goding


Original Title: Monoclonal Antibodies

Monoclonal Antibodies now have applications in virtually all areas of biology and medicine, and much of the world's biotechnology industry has its foundations in the exploitation of this technology. The Third Edition of this well established book meets the needs of both newcomers to the area and experienced researchers, by providing an integrated treatment of both the production and application of monoclonal antibodies. As in previous editions, detailed and critical accounts of the theory, production, purification, fragmentation, storage and radiolabelling of monoclonal antibodies are given, along with descriptions of their use in antigen characterization, affinity chromatography and immunofluorescence. The present volume has been comprehensively updated to cover recent rapid advances, particularly with respect to the applications of molecular biology, the use of antibodies in closing and heterologous expression of genes, immunohistology and phage display libraries. Since the previous edition, there has been a growing trend towards the replacement of procedures using radioactive isotopes, and the current edition incorporates these newer technologies. The text is oriented towards problems solving, and makes it easy to adapt each procedure to individual needs. Extensive cross-referencing, a glossary and a comprehensive index make this book an essential reference. This book will be vital both for laboratories already producing or using monoclonal antibodies, and for workers in many disciplines who are contemplating their use. Provides an integrated treatment of both the production and application of monoclonals in cell biology, biochemistry, and immunology Gives detailed and critical accounts of the theory, production, purification, storage, and relabelling of monoclonals, and their use in antigen characterization, affinity chromorography, and immunofluroscence Comprehensively updated to cover the rapid advances that have occurred since the publication of the Second Edition

Drug Delivery Systems Third Edition

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Author: Vasant V. Ranade
Publisher: CRC Press
ISBN: 1439806187
Size: 55.76 MB
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Drug Delivery Systems Third Edition by Vasant V. Ranade


Original Title: Drug Delivery Systems Third Edition

Drug delivery technologies represent a vast, vital area of research and development in pharmaceuticals. The demand for innovative drug delivery systems continues to grow, driving a variety of new developments. Drug Delivery Systems, Third Edition provides a comprehensive review of the latest research and development on drug delivery systems. Coverage includes liposomal, transmucosal, transdermal, oral, polymeric, and monoclonal antibody directed delivery. Each chapter provides a table of marketed and investigational products with numerous practical examples. The book also provides readers with a multitude of possible drug delivery systems that can be used to improve therapeutics, along with global and regulatory perspectives. This third edition contains a chapter on nanoscience and technology for drug delivery along with cutting-edge business intelligence and strategies. Written in a straightforward manner, the authors provide a global perspective on current and future advances and market opportunities. Supplying a cogent overview of the field and extensive guidance on where to get more information, it is an essential resource for anyone venturing into this area of drug development.

Illustrated Dictionary Of Immunology Third Edition

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Author: Julius M. Cruse
Publisher: CRC Press
ISBN: 9780849379888
Size: 76.23 MB
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Illustrated Dictionary Of Immunology Third Edition by Julius M. Cruse


Original Title: Illustrated Dictionary Of Immunology Third Edition

From the beginning, immunologists have maintained a unique nomenclature that has often mystified and even baffled their colleagues in other fields, causing them to liken immunology to a black box. With more than 1200 illustrations, the Illustrated Dictionary of Immunology, Third Edition provides immunologists and nonimmunologists a single-volume resource for the many terms encountered in contemporary immunological literature. Encyclopedic in scope and including more than 1200 illustrations, the content ranges from photographs of historical figures to molecular structures of recently characterized cytokines, the major histocompatibility complex molecules, immunoglobulins, and molecules of related interest to immunologists. These descriptive illustrations provide a concise and thorough understanding of the subject. To reflect modern advances, the third edition includes entries on immunopharmacology, newly described interleukins, comparative immunology, immunity to infectious diseases, and expanded definitions in all of the immunological subspecialities. Providing unprecedented breadth and detail, this readily accessible book is not only a pictorial reference but also a primary resource.

Gene Biotechnology Third Edition

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Author: William Wu
Publisher: CRC Press
ISBN: 1439848327
Size: 55.84 MB
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Gene Biotechnology Third Edition by William Wu


Original Title: Gene Biotechnology Third Edition

Covering state-of-the-art technologies and a broad range of practical applications, the Third Edition of Gene Biotechnology presents tools that researchers and students need to understand and apply today's biotechnology techniques. Many of the currently available books in molecular biology contain only protocol recipes, failing to explain the principles and concepts behind the methods outlined or to inform the reader of possible pitfalls in the methods described. Filling these gaps, this book: Discusses a wide variety of approaches, from very basic methods to the latest, most sophisticated technologies Contains clearly detailed, step-by-step protocols with helpful troubleshooting tips Addresses the needs of researchers in academic and commercial environments Guides graduate students in designing, implementing, and evaluating experimental projects. Each chapter covers the principles underlying methods and techniques, and includes step-by-step descriptions of each protocol, notes, tips, and a troubleshooting guide. The book includes sections on how to write a research paper for publication in English-language journals, how to protect research discoveries and inventions via patents, and practical methods of bio-calculation. Written by a team of internationally recognized scientists, Gene Biotechnology presents protocols as well as clear and simple explanations of the key principles and concepts behind the methods. It is a single, logically organized source for the most important new methodologies. This unique resource provides the tools to help ensure success in contemporary molecular and cellular biology research.

Monoclonal Antibodies Against Bacteria

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Author: Alberto J. L. Macario
Publisher: Elsevier
ISBN: 148325738X
Size: 60.25 MB
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Monoclonal Antibodies Against Bacteria by Alberto J. L. Macario


Original Title: Monoclonal Antibodies Against Bacteria

Monoclonal Antibodies Against Bacteria, Volume II provides the basis for understanding new developments of practical importance in the health sciences within the area of microbiology and infectious diseases, focusing on advances made possible by monoclonal antibodies. This 12-chapter volume starts with the analysis of streptococcal antigens implicated in the causation of rheumatic fever and heart disease to find ways of inducing protective immunity. The next chapters deal with the detection of staphylococcal enterotoxins in foods and treatment of staphylococcal food poisoning, the classification of meningococcal isolates associated with meningitis and related disorders, and the immunology of brucellosis with emphasis on the problem of distinguishing antibrucella antibodies elicited by vaccination of cattle from antibodies elicited by infection. These topics are followed by discussions of the diagnostic and epidemiologic studies of legionellosis; the identification of antigens in gram-negative bacteria; and the development of means to study and control infections by Pseudomonas in cystic fibrosis and other pathologic conditions. Other chapters explore the analysis of toxigenicity and neutralization of botulinum toxin, the pathogenetic role of Escherichia coli's pili, and study of its antigens to understand regulatory networks of the immune system involving antiidiotypic antibodies. The remaining chapters consider the elucidation of antigenic mosaics of archaebacteria and identification of their molecular signatures in their ecological niches and other life forms. These chapters also look into the combination of bacterial genetics with hybridoma technology for elucidating structure-function relationships in membrane molecules, as well as the strategies, methods, quality control, and other practical aspects connected with industrial production of monoclonal antibodies against bacteria. This book will prove useful to internists, pediatricians, surgeons, dentists, veterinarians, clinical pathologists, and laboratory technologists.

Monoclonal Antibodies

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Author: Steven Shire
Publisher: Woodhead Publishing
ISBN: 0081002971
Size: 42.50 MB
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Monoclonal Antibodies by Steven Shire


Original Title: Monoclonal Antibodies

Monoclonal antibodies (MAbs) are currently the major class of protein bio therapeutic being developed by biotechnology and pharmaceutical companies. Monoclonal Antibodies discusses the challenges and issues revolving around development of a monoclonal antibody produced by recombinant DNA technology into a therapeutic agent.This book covers downstream processing which includes design of processes to manufacture the formulation, formulation design, fill and finish into closure systems and routes of administration. The characterization of the final drug product is covered where the use of biophysical methods combined with genetic engineering is used to understand the solution properties of the formulation. The latter has become very important since many indications such as arthritis and asthma require the development of formulations for subcutaneous delivery (SC). The development of formulations for IV delivery is also important and comes with a different set of challenges. The challenges and strategies that can overcome these limitations are discussed in this book, starting with an introduction to these issues, followed by chapters detailing strategies to deal with them. Subsequent chapters explore the processing and storage of mAbs, development of delivery device technologies and conclude with a chapter on the future of mAbs in therapeutic remedies. Discusses the challenges to develop MAbs for intravenous (IV) and subcutaneous delivery (SC) Presents strategies to meet the challenges in development of MAbs for SC and IV administration Discusses the use of biophysical analytical tools coupled with MAb engineering to understand what governs MAb properties at high concentration

Cell Wall Deficient Forms Third Edition

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Author: Lida H. Mattman
Publisher: CRC Press
ISBN: 9780849387678
Size: 53.24 MB
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Cell Wall Deficient Forms Third Edition by Lida H. Mattman


Original Title: Cell Wall Deficient Forms Third Edition

Numerous infectious diseases are described as idiopathic, meaning that "the cause is a complete mystery." For many idiopathic diseases, the causes become clear when certain techniques are applied to the patient's blood or other tissues. Cell Wall Deficient Forms: Stealth Pathogens, Third Edition describes these techniques. In the case of tuberculosis, a disease that has recently regained importance because the strains have acquired antibiotic resistance, the book describes a method that is widely used abroad. This method typically renders the diagnosis within 72 hours. The book examines a plethora of issues and provides answers to the following questions: What organism should be added to the childhood vaccine, especially for boys? What bacteria in its pleomorphic state is found in direct smears of synovial fluid of rheumatoid arthritis cases? In which chronic diseases ( presently considered as being of unknown origin) is an acid-fast organism routinely found in smears of 72 hour blood cultures? Which "bacterium" has a life cycle in the human erythrocyte as complex as that of Plasmodium malaria? Which common pathogen's L Form can permanently damage myocardium mammaliam? Cell Wall Deficient Forms: Stealth Pathogens, Third Edition discloses significant aspects of microbiology, aspects that are not taught, and which go unrecognized in the clinical laboratory.

Handbook Of Laboratory Animal Science Volume I Third Edition

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Author: Jann Hau
Publisher: CRC Press
ISBN: 9781420084566
Size: 78.45 MB
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Handbook Of Laboratory Animal Science Volume I Third Edition by Jann Hau


Original Title: Handbook Of Laboratory Animal Science Volume I Third Edition

Laboratory animal testing provides most of our current knowledge of human physiology, microbiology, immunology, pharmacology, and pathology. From studies of genetics in fruit flies to studies of cellular processes in genetically modified mice to recent dramatic developments in genetics, translational research, and personalized medicines, biomedical research involving animals remains absolutely essential for the advancement of the medical, veterinary, agricultural, and biological sciences and all rely on access to high-quality laboratory animals as models for humans. Rooted in the principle that good science can only be performed in environments that promote good animal welfare, this third edition of the bestselling Handbook of Laboratory Animal Science, Vol. 1, Essential Principles and Practices emphasizes the importance of implementing the three R’s: replacing live animals with alternative methods, reducing the number of animals used, and refining techniques to minimize animal discomfort, and integrates these humane principles into almost every chapter. See what's new in the Third Edition: New chapters: Applications of Radio-Telemetry in Small Laboratory Animals, Generation and analysis of genetically modified mice, and Physiological, Hematological, and Clinical Chemistry Parameters Additional mateiral on the international harmonization of practices and on the continued implementation of the refinement, reduction, and replacement of animal usage in laboratories Sixteen page color insert Relevant to virtually all areas of laboratory science and forming the cornerstone of laboratory animal science, each individual chapter focuses on an important subdiscipline of laboratory animal science including humane laws and guidelines; non-surgical, surgical, microsurgical, and post-mortem procedures; genetic modification; nutrition, feeding, and environmental factors; experiment design and alternative methods; and analgesia, anesthesia, and euthanasia. Each chapter can be read in series or as a stand alone text. A truly international effort from world renowned contributors, Handbook of Laboratory Animal Science, Vol. 1, Essential Principles and Practices, Third Edition is useful as a textbook in laboratory animal science courses for postgraduate and undergraduate students, as a handbook for scientists who work with animals in their research, and for university veterinarians, regulators, and other specialists in laboratory animal science.

The Lock And Key Of Medicine

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Author: Lara V. Marks
Publisher: Yale University Press
ISBN: 0300213522
Size: 44.99 MB
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The Lock And Key Of Medicine by Lara V. Marks


Original Title: The Lock And Key Of Medicine

This book is the first to tell the extraordinary yet unheralded history of monoclonal antibodies. Often referred to as Mabs, they are unfamiliar to most nonscientists, yet these microscopic protein molecules are everywhere, quietly shaping our lives and healthcare. Discovered in the mid-1970s in the laboratory where Watson and Crick had earlier unveiled the structure of DNA, Mabs have radically changed understandings of the pathways of disease. They have enabled faster, cheaper, and more accurate clinical diagnostic testing on a vast scale. And they have played a fundamental role in pharmaceutical innovation, leading to such developments as recombinant interferon and insulin, and personalized drug therapies such as Herceptin. Today Mabs constitute six of the world’s top ten blockbuster drugs and make up a third of new introduced treatments. Lara V. Marks recounts the risks and opposition that a daring handful of individuals faced while discovering and developing Mabs, and she addresses the related scientific, medical, technological, business, and social challenges that arose. She offers a saga of entrepreneurs whose persistence and creativity ultimately changed the healthcare landscape and brought untold relief to millions of patients. Even so, as Marks shows, controversies over Mabs remain, and she examines current debates over the costs and effectiveness of these innovative drugs.

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