Mutagenicity Assays And Applications

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Author: Ashutosh Kumar
Publisher: Academic Press
ISBN: 0128092602
Size: 67.89 MB
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Mutagenicity Assays And Applications by Ashutosh Kumar


Original Title: Mutagenicity Assays And Applications

Mutagenicity: Assays and Applications presents an extensive examination of the detection, assessment and future of mutagenicity, particularly as it concerns human health and the environment. Chapters focused on specific types of mutagens or testing methods for their detection collectively explore the current state of human and environmental mutagenesis, future perspectives and regulatory needs. The test procedures for measuring mutagenicity, their advantages and limitations are described with practical and procedural detail, along with their presentation and data processing aspects. It is an essential reference covering the breadth and depth of the field of mutagenicity studies and regulation. By providing both important introductory material and practical assays and applications, this book is useful to graduate students, academic and industry researchers and regulators at various stages of their careers, leading to improved risk assessment and regulation. Presents an up-to-date and in-depth review of the current state of mutagenesis research Draws upon the combined experience and expertise of an international group of highly respected editors and chapter authors Provides an introduction to the concept of mutagenesis with particular consideration given to novel chemicals and materials

Mutagenicity

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Author: Rishi Shanker
Publisher: Academic Press
ISBN: 9780128092521
Size: 23.50 MB
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Mutagenicity by Rishi Shanker


Original Title: Mutagenicity

Mutagenicity: Assays and Applications presents an extensive examination of the detection, assessment and future of mutagenicity, particularly as it concerns human health and the environment. Chapters focused on specific types of mutagens or testing methods for their detection collectively explore the current state of human and environmental mutagenesis as well as future perspectives and regulatory needs. The test procedures for measuring mutagenicity, their advantages and limitations are described with practical and procedural detail along with the presentation and data processing aspects. Mutagenicity: Assays and Applications is an essential reference covering the breadth and depth of the field of mutagenicity studies and regulation. By providing both important introductory material along with practical assays and applications, the book is useful to graduate students, academic and industry researchers and regulators at various stages of their careers, leading to improved risk assessment and regulation. Presents an up-to-date and in-depth review of the current state of mutagenesis research Draws upon the combined experience and expertise of an international group of highly respected editors and chapter authors Provides an introduction to the concept of mutagenesis with particular consideration given to novel chemicals and materials

Mutagenicity

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Author: John A. Heddle
Publisher: Elsevier
ISBN: 1483271226
Size: 32.28 MB
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Mutagenicity by John A. Heddle


Original Title: Mutagenicity

Mutagenicity: New Horizons in Genetic Toxicology provides an overview of the various applications and studies in the field of genetic toxicology and environmental mutagenesis. The book is composed of selected scientific papers written by experts in the field. The text presents topics on naturally occurring mutagens; occupational carcinogen; and evaluation of cooking methods. Experiments on mammalian cell mutation; chromosomal aberrations; and organisms that can be used as environmental monitors of toxicity are discussed as well. Ecologists, environmental and sanitary engineers, toxicologists, and anyone interested in environmental mutagenesis, genetic toxicology, occupational health, or the regulation of toxic substances will find the book a good source of insight.

Development And Applications Of Mutagenicity And Carcinogenicity Bioassays For Human Health Risk Assessment

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ISBN:
Size: 11.11 MB
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Development And Applications Of Mutagenicity And Carcinogenicity Bioassays For Human Health Risk Assessment by


Original Title: Development And Applications Of Mutagenicity And Carcinogenicity Bioassays For Human Health Risk Assessment

Young children are particularly sensitive to environmental pollutants. They can directly ingest soil by putting dirty hands and objects in their mouths. The reliance on animal derived models for human health risk and exposure assessment has several limitations. In this investigation, a tool-kit was developed and optimised to facilitate more accurate, reliable and representative predictions of soil contaminants that might pose a significant hazard to young children. The tool-kit was developed and optimised using an in vitro human digestion bioassay. This procedure was followed by the optimisation of several mutagenicity bioassays to link to the bioaccessible fraction which quantified by the in vitro bioassay. The application of novel and sensitive environmental-based biosensors requires them to work in parallel with effective and proven extraction techniques. In this study, chemical analysis was used to quantify the bioaccessible (human assimilated portion) of pollutants in soils. Acute toxicity was measured using constitutively marked bioluminescent bacterial biosensors and these were indicative of the total contaminant burden. A range of mutagenic assays were applied and optimised. In the Ames assay, any compound exhibiting a greater than two-fold increase in the number of revertants colonies over the number of spontaneous revertants was considered as a mutagen. Mutagenic-responsive SOS-lux based microbial biosensors were compared to the Ames assay. Mutagenicity assessment of a broad range of environmental pollutants (i.e. B[a]P, DiB(a,h)A, B[a]A, Ni and Cu), was performed using four SOS-lux microbial biosensors; E. coli DPD1718, E. coli K12C600, S. aureus pAmiUmuC and S. aureus pAmiRecA. The results substantiated that the four biosensors were unable to be induced by these pollutants. Nevertheless, E. coli DPD1718 and E. coli K12C600 were successfully induced by Mitomycin C (MMC) in a dose response manner.

Advances In Erythromycin Research And Application 2011 Edition

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Publisher: ScholarlyEditions
ISBN: 1464932956
Size: 80.89 MB
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Original Title: Advances In Erythromycin Research And Application 2011 Edition

Advances in Erythromycin Research and Application: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Erythromycin in a concise format. The editors have built Advances in Erythromycin Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Erythromycin in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Erythromycin Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Issues In General Economic Research And Application 2011 Edition

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Publisher: ScholarlyEditions
ISBN: 1464965048
Size: 30.17 MB
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Issues In General Economic Research And Application 2011 Edition by


Original Title: Issues In General Economic Research And Application 2011 Edition

Issues in General Economic Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about General Economic Research and Application. The editors have built Issues in General Economic Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about General Economic Research and Application in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in General Economic Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Applications Of Toxicogenomics In Safety Evaluation And Risk Assessment

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Author: Darrell R. Boverhof
Publisher: John Wiley & Sons
ISBN: 9781118008980
Size: 44.50 MB
Format: PDF
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Applications Of Toxicogenomics In Safety Evaluation And Risk Assessment by Darrell R. Boverhof


Original Title: Applications Of Toxicogenomics In Safety Evaluation And Risk Assessment

This book provides a timely overview of toxicogenomics, with special emphasis on the practical applications of this technology to the risk assessment process. Introductory sections are followed by a series of chapters highlighting practical and systematic applications of toxicogenomics in informing the risk assessment process – including the areas of mutagenicity, carcinogenicity, endocrine toxicity, organ-specific toxicity, population monitoring, and ecotoxicology. The book concludes with approaches for the integration of this technology in safety evaluation studies, and an outlook on how toxicogenomics and complementary technologies can reframe the current risk assessment paradigm.

Principles Of Genetic Toxicology

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Author: D. Brusick
Publisher: Springer Science & Business Media
ISBN: 1489919805
Size: 59.26 MB
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Principles Of Genetic Toxicology by D. Brusick


Original Title: Principles Of Genetic Toxicology

The field of genetic toxicology has gone through remarkable development in the seven years since the appearance of the first edition of Principles of Genetic Toxicology. One branch of toxicology research, chemical mutagenesis, has been elucidated and expanded as a result of increased effort, testing, and the sharing of data. This expansion has occurred not only in the industrialized countries, but also in countries that are comparatively less advanced in scientific implementation. These developing countries have taken advan tage of the basic practical methods that were so well described in the first edition of this work. It is significant to note how many centers have been established throughout the world and are now studying the basic concepts and applying them to practical problems such as the detection of genetic effects caused by exposure to chemicals. In fact, there are now toxicology training centers in twelve countries. Genetic toxicology, in addition to being investigated as a science unto itself, has been taught to people in the applied fields so that these techniques may be put to use in solving other biological problems. For these reasons, it is most useful to have an update of the basic methods and their development. Dr. Brusick should be congratulated for doing such an excellent job of assembling a text that will be worthwhile to any researcher who is interested in the principles of genetic toxicology. Alexander Hollaender Council for Research Planning in Biological Sciences, Inc. Washington, D. C.

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