Novel Anticancer Agents

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Author: Alex A. Adjei
Publisher: Academic Press
ISBN: 0080537758
Size: 21.97 MB
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Novel Anticancer Agents by Alex A. Adjei


Original Title: Novel Anticancer Agents

This book offers pertinent basic science information on strategies used for the rational design and discovery of novel anticancer agents, and, in addition, translational studies involving clinical trial design and execution with these novel, mostly cytostatic agents. This book covers basic science strategies that are being used in drug discovery and preclinical evaluation focused on novel molecular targets, as well as clinical trial methodology including clinical pharmacokinetics and imaging to address issues of efficacy evaluation of the new, relatively non-cytotoxic anticancer agents. At present, there is no book that provides such an integration of basic and clinical studies of novel anticancer agents, covering both drug discovery and translational research extensively. * Addresses the critical issues involved in the development of novel agents for cancer therapy by experts in the field * Presents drug discovery strategies * Discusses regulatory issues surrounding drug development *

Novel Anticancer Agents That Block Dissociation Of Hsp90 From Estrogen Receptors In Breast Cancers

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Novel Anticancer Agents That Block Dissociation Of Hsp90 From Estrogen Receptors In Breast Cancers by


Original Title: Novel Anticancer Agents That Block Dissociation Of Hsp90 From Estrogen Receptors In Breast Cancers

Heat shock protein 90 (Hsp90) is a chaparone protein that facilitates the folding of estrogen receptors (ERs) and other proteins involved in breast cancer proliferation. This protein is under investigation as a target of anticancer drugs because breast cancer cells contain Hsp90 in an activated high affinity conformation that is particularly susceptible to Hsp90 inhibitors. These inhibitors include the anticancer agent geldanamycin (GDM), which is thought to inhibit the proliferation of cancer cells in part by blocking agonist-induced release of steroid hormone receptors such as ERs from Hsp90. To further stabilize this interaction, we synthesized estrogen receptor ligands coupled to GDM to enforce heterodimerization of ER and Hsp90 in mammalian cells. We demonstrated that at a concentration of 10 micromolar, an estrone (E1)-GDM chimera can heterodimerize recombinant ER and Hsp90 proteins in vitro. Moreover, competition experiments established that this compound stabilizes interactions between ERs and Hsp90 in human cells. These studies demonstrated that bifunctional small molecules can affect ERs by heterodimerization with Hsp90, providing a new strategy for inhibiting ERs involved in breast cancer proliferation.

Anticancer Agents From Natural Products Second Edition

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Author: Gordon M. Cragg
Publisher: CRC Press
ISBN: 1439813833
Size: 61.35 MB
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Anticancer Agents From Natural Products Second Edition by Gordon M. Cragg


Original Title: Anticancer Agents From Natural Products Second Edition

The approach to drug discovery from natural sources has yielded many important new pharmaceuticals inaccessible by other routes. In many cases the isolated natural product may not be an effective drug for any of several reasons, but it nevertheless may become a drug through chemical modification or have a novel pharmacophore for future drug design. In summarizing the status of natural products as cancer chemotherapeutics, Anticancer Agents from Natural Products, Second Edition covers the: History of each covered drug—a discussion of its mechanism on action, medicinal chemistry, synthesis, and clinical applications Potential for novel drug discovery through the use of genome mining as well as future developments in anticancer drug discovery Important biosynthetic approaches to "unnatural" natural products Anticancer Agents from Natural Products, Second Edition discusses how complex target-oriented synthesis—enabled by historic advances in methodology—has enormously expanded the scope of the possible. This book covers the current clinically used anticancer agents that are either natural products or are clearly derived from natural product leads. It also reviews drug candidates currently in clinical development since many of these will be clinically used drugs in the future. Examples include the drugs etoposide and teniposide derived from the lead compound podophyllotoxin; numerous analogs derived from taxol; topotecan, derived from camptothecin; and the synthetic clinical candidates, E7389 and HTI-286, developed from the marine leads, halichondrin B and hemiasterlin.

Cancer Chemotherapy

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Author: Rachel Airley
Publisher: John Wiley & Sons
ISBN: 0470092564
Size: 49.78 MB
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Cancer Chemotherapy by Rachel Airley


Original Title: Cancer Chemotherapy

This textbook is a clear and accessible introduction to the scientific and clinical aspects of the creation, development and administration of drugs or drug regimens used in the treatment of cancer. Unique in its approach, this book enables the student to gain an understanding of the pathological, physiological and molecular processes governing malignancy, whilst also introducing the role of health professionals and scientists in the research and treatment of cancer. The book consolidates all the essential information necessary for a full understanding of cancer chemotherapy, providing an informative, inexpensive and up-to-date coverage of the subject aimed at an undergraduate level readership. Key Features: Incorporates numerous diagrams, tables and illustrations to aid understanding. Examines key pharmacological and pharmaceutical issues such as dosing, toxicity and preparation of anti-cancer drugs. Includes a key chapter of practice essay questions to ease revision. Comprehensive coverage of drugs currently in pre-clinical and clinical development. An indispensable text for undergraduate students studying pharmacy and medicine as well as those doing courses such as molecular biology, biomedical sciences and pharmacology which cover aspects of oncology.

Novel Anticancer Drug Protocols

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Author: John K. Buolamwini
Publisher: Springer Science & Business Media
ISBN: 1592593801
Size: 15.16 MB
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Novel Anticancer Drug Protocols by John K. Buolamwini


Original Title: Novel Anticancer Drug Protocols

This book not only surveys the whole arena of novel anticancer drug targets, but also presents a wide-ranging selection of cuttingedge techniques currently being applied throughout novel antitumor drug discovery and development. The methods are applied to experiments involving such topics as immunotherapy, angiogenesis, cancer metastasis, the cell cycle, signal transduction inhibitors, apoptosis, antibodies, antisense molecules, microarray gene expression, flow cytometry, and PET imaging for cancer target validation. There are also proven methods for the preclinical identification of drug targets. Validate new drug targets both preclinically and clinically Identify novel anticancer drug targets in preclinical stages Follow proven instructions to obtain successful results and avoid failure.

Frontiers In Anti Cancer Drug Discovery

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Author: Atta-ur-Rahman
Publisher: Bentham Science Publishers
ISBN: 1608058840
Size: 39.64 MB
Format: PDF
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Frontiers In Anti Cancer Drug Discovery by Atta-ur-Rahman


Original Title: Frontiers In Anti Cancer Drug Discovery

Frontiers in Anti-Cancer Drug Discovery is an Ebook series devoted to publishing the latest and the most important advances in Anti-Cancer drug design and discovery. Eminent scientists write contributions on all areas of rational drug design and drug discovery, including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. The Ebook series should prove to be of interest to all pharmaceutical scientists involved in research in Anti-Cancer drug design and discovery. Each volume is devoted to the major advances in Anti-Cancer drug design and discovery. The Ebook series is essential reading for all scientists involved in drug design and discovery who wish to keep abreast of rapid and important developments in the field.

Handbook Of Anticancer Drugs From Marine Origin

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Author: Se-Kwon Kim
Publisher: Springer
ISBN: 3319071459
Size: 21.62 MB
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Handbook Of Anticancer Drugs From Marine Origin by Se-Kwon Kim


Original Title: Handbook Of Anticancer Drugs From Marine Origin

This timely desk reference focuses on marine-derived bioactive substances which have biological, medical and industrial applications. The medicinal value of these marine natural products are assessed and discussed. Their function as a new and important resource in novel, anticancer drug discovery research is also presented in international contributions from several research groups. For example, the potential role of Spongistatin, Apratoxin A, Eribulin mesylate, phlorotannins, fucoidan, as anticancer agents is explained. The mechanism of action of bioactive compounds present in marine algae, bacteria, fungus, sponges, seaweeds and other marine animals and plants are illustrated via several mechanisms. In addition, this handbook lists various compounds that are active candidates in chemoprevention and their target actions. The handbook also places into context the demand for anticancer nutraceuticals and their use as potential anti-cancer pharmaceuticals and medicines. This study of advanced and future types of natural compounds from marine sources is written to facilitate the understanding of Biotechnology and its application to marine natural product drug discovery research.

Rhabdoid Tumors New Insights For The Healthcare Professional 2011 Edition

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Publisher: ScholarlyEditions
ISBN: 1464918546
Size: 63.96 MB
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Rhabdoid Tumors New Insights For The Healthcare Professional 2011 Edition by


Original Title: Rhabdoid Tumors New Insights For The Healthcare Professional 2011 Edition

Rhabdoid Tumors: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Rhabdoid Tumors in a compact format. The editors have built Rhabdoid Tumors: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Rhabdoid Tumors in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Rhabdoid Tumors: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Phase I Cancer Clinical Trials

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Author: Elizabeth A. Eisenhauer
Publisher: Oxford University Press
ISBN: 0199359032
Size: 16.89 MB
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Phase I Cancer Clinical Trials by Elizabeth A. Eisenhauer


Original Title: Phase I Cancer Clinical Trials

Phase I trials are a critical first step in the study of novel cancer therapeutic approaches. Their primary goals are to identify the recommended dose, schedule and pharmacologic behavior of new agents or new combinations of agents and to describe the adverse effects of treatment. In cancer therapeutics, such studies have particular challenges. Due to the nature of the effects of treatment, most such studies are conducted in patients with advanced malignancy, rather than in healthy volunteers. Further, the endpoints of these trials are usually measures adverse effects rather than molecular target or anti-tumor effects. These factors render the design, conduct, analysis and ethical aspects of phase I cancer trials unique. As the only comprehensive book on this topic, Phase I Cancer Clinical Trials is a useful resource for oncology trainees or specialists interested in understanding cancer drug development. New to this edition are chapters on Phase 0 Trials and Immunotherapeutics, and updated information on the process, pitfalls, and logistics of Phase I Trials

Chemistry And Pharmacology Of Anticancer Drugs

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Author: David E. Thurston
Publisher: CRC Press
ISBN: 1420008900
Size: 29.77 MB
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Chemistry And Pharmacology Of Anticancer Drugs by David E. Thurston


Original Title: Chemistry And Pharmacology Of Anticancer Drugs

While drug therapies developed in the last 50 years have markedly improved the management of some types of cancers, treatment outcomes, and drug side-effects for the most common types remain unacceptable. However, recent technological advances are leading to improved therapies based on targeting distinct biological pathways in cancer cells. Chemistry and Pharmacology of Anticancer Drugs is a comprehensive survey of all families of anticancer agents currently in use or in advanced stages of clinical trials, including biologicals. The book is unique in providing molecular structures for all anticancer drugs, discussing them in terms of history, chemistry, mechanism of action, structure-function relationships, and pharmacology. It also provides some relevant information on side effects, dosing, and formulation. The author, a renowned scientist in cancer research and drug development, also provides up-to-date information on the drug discovery process, including new research tools, tumor-targeting strategies, and fundamental concepts in the emerging areas of personalized medicine (e.g., oncogenomics) and chemoprevention. Chemistry and Pharmacology of Anticancer Drugsis an indispensable resource for cancer researchers, medicinal chemists, and other biomedical scientists involved in the development of new anticancer treatments. Its breadth of coverage also makes it suitable for undergraduate and postgraduate courses in medicine, pharmacy, nursing, and related disciplines.

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