Nucleosomes Histones Chromatin

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Author: Carl Wu
Publisher: Academic Press
ISBN: 0123919401
Size: 31.42 MB
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Nucleosomes Histones Chromatin by Carl Wu


Original Title: Nucleosomes Histones Chromatin

This new volume of Methods in Enzymology continues the legacy of this premier serial by containing quality chapters authored by leaders in the field. The first of 2 volumes covering nucleosomes, histones and chromatin, it has chapters on methods applied to the study of protein arginine methylation, high-resolution identification of intra- and interchromosomal DNA interactions by 4C technology, and peptide arrays to interrogate the binding specificity of chromatin-binding proteins. Continues the legacy of this premier serial by containing quality chapters authored by leaders in the field The first of 2 volumes covering nucleosomes, histones and chromatin Chapters on methods applied to the study of protein arginine methylation, high-resolution identification of intra- and interchromosomal DNA interactions by 4C technology, and peptide arrays to interrogate the binding specificity of chromatin-binding proteins

Nucleosomes Histones And Chromatin

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Publisher: Academic Press
ISBN: 0123919398
Size: 34.82 MB
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Nucleosomes Histones And Chromatin by


Original Title: Nucleosomes Histones And Chromatin

This new volume of Methods in Enzymology continues the legacy of this premier serial by containing quality chapters authored by leaders in the field. The volume covers nucleosomes, histones and chromatin and has chapters on dynamic mapping of histone-DNA interactions in nucleosomes by unzipping single molecules of DNA, digital DNase technology, and genome-wide analysis of chromatin transition. Contains quality chapters authored by leaders in the field The volume covers nucleosomes, histones and chromatin Has chapters on dynamic mapping of histone-DNA interactions in nucleosomes by unzipping single molecules of DNA, digital DNase technology, and genome-wide analysis of chromatin transition

Nucleosomes

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Author: Paul M. Wassarman
Publisher: Academic Press
ISBN:
Size: 68.14 MB
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Nucleosomes by Paul M. Wassarman


Original Title: Nucleosomes

The critically acclaimed laboratory standard, Methods in Enzymology, is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. The series contains much material still relevant today - truly an essential publication for researchers in all fields of life sciences.

The Nucleolus

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Author: Mark O. J. Olson
Publisher: Springer Science & Business Media
ISBN: 9780306478734
Size: 74.91 MB
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The Nucleolus by Mark O. J. Olson


Original Title: The Nucleolus

As the first comprehensive overview of the nucleolus since 1985, The Nucleolus covers our current understanding of the cell nucleolus, including its role in ribosome assembly and its additional newly-discovered activities. The eighteen chapters have been written by experts who are actively engaged in research on the nucleolus and have an in depth review of the following topics: - nucleolar ultrastructure and dynamics, - behavior during mitosis, - ribosomal DNA gene and chromatin structure, - pre-ribosomal RNA transcription, - processing and modification, - ribosome assembly, - small nucleolar RNAs, - proteomics and non-traditional functions of the nucleolus. Separate chapters are also provided for yeast and higher eukaryotes on many topics. The Nucleolus will appeal not only to scientists directly engaged in nucleolar research, but also those working in related areas such as gene expression, protein biosynthesis, ribosome structure, transcription, chromatin structure, molecular genetics and the structure and functions of the cell nucleus in general.

Molecular Biology And Biotechnology

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Author: Robert A. Meyers
Publisher: John Wiley & Sons
ISBN: 9780471186342
Size: 18.92 MB
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Molecular Biology And Biotechnology by Robert A. Meyers


Original Title: Molecular Biology And Biotechnology

Essential for the top of every desk and laboratory bench, this single volume reference is the first and last resource required to answer any question relating to molecular biology, biotechnology, or molecular medicine. This work contains the theory and techniques for understanding, modifying, manipulating, expressing, and synthesizing biological molecules, conformations, and aggregates. Over 250 carefully reviewed articles written by 378 eminent scientists in the field, provide detailed and readable coverage of today's most relevant topics including life processes at the molecular level, genetic disease diagnosis and genetic therapy, the theory and techniques for understanding, manipulating, and synthesizing biological molecules and their aggregates.

The Nucleosome

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Author: A.P. Wolffe
Publisher: Elsevier
ISBN: 9780080537849
Size: 22.10 MB
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The Nucleosome by A.P. Wolffe


Original Title: The Nucleosome

This is the first in a series of volumes concerning the properties of the eukaryotic nucleus. Contributions from several of the most active laboratories are brought together to present a focused overview of a selected aspect of nuclear structure and function.

From Nucleosomes To Chromatin Fibers Molecular Dynamics And Monte Carlo Simulations Of Nucleosome Organization And Interactions

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ISBN:
Size: 35.88 MB
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From Nucleosomes To Chromatin Fibers Molecular Dynamics And Monte Carlo Simulations Of Nucleosome Organization And Interactions by


Original Title: From Nucleosomes To Chromatin Fibers Molecular Dynamics And Monte Carlo Simulations Of Nucleosome Organization And Interactions

Chromosomes consist of a chain of nucleosomes, in which DNA wraps almost twice around a histone protein core. Nucleosomes are stable complexes and their position along the DNA regulates DNA accessibility. The underlying mechanisms of this process are still not understood well. In this thesis, molecular dynamics, steered molecular dynamics and Monte Carlo simulations were conducted to elucidate nucleosome organization and the folding of nucleosome chains into chromatin fibers at different length scales. The all-atom resolution of molecular dynamics simulations revealed a novel map of histone-DNA interaction sites extending experimental findings. By applying external forces the complete DNA unwrapping from the protein core at atomic resolution was investigated. This revealed intermediates of the pathway and an important contribution of the unstructured histone tails to nucleosome stability. Simulations of stretching coarse-grained chromatin fibers showed that experimental force-extension curves alone are insufficient to identify fiber geometry parameters and internucleosomal interaction strength. The chromatin fiber model was extended by a new description for DNA electrostatics to enable the translocation of nucleosomes within the fiber. The effect of this process on the stability of the fiber was strongly dependent on its geometry.

Epigenetics

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Author: Jeffrey Craig
Publisher: Horizon Scientific Press
ISBN: 1904455883
Size: 44.91 MB
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Epigenetics by Jeffrey Craig


Original Title: Epigenetics

Epigenetics is the study of changes in gene expression caused by mechanisms other than changes in the DNA sequence. Epigenetics is a rapidly advancing field with an increasing impact on biological and medical research. The editors of this book have assembled top-quality scientists from diverse fields of epigenetics to produce a major new volume. Comprehensive and cutting-edge, the 26 chapters in this book constitute a key reference manual for everyone involved in epigenetics, DNA methylation, cancer epigenetics, and related fields. Topics include: early life environment * DNA methylation and behavior * histone acetyltransferase biology * transgenerational epigenetic inheritance * mammalian X inactivation * epigenetic memory in plants * polycomb-group regulation * centromeres and telomeres * DNA sequence contribution to nucleosome distribution * macrosatellite epigenetics * histones * cell-fate specification and reprogramming * DNA methylation in cancer * variant histone H2A and cancer development * RNA modification * paramutation in plants * DNMT3L dependent methylation during gametogenesis * non-coding RNA * bisulphite-enabled technologies * rapid analysis of DNA methylation * microarray mapping * DNA methylation profiling * ChIP-sequencing * genome-wide DNA methylation analysis * epigenetics in maize. In addition there are useful chapters on bioinformatics in epigenomics, online resources and tools for epigeneticists, and educational resources for epigenetics. This up-to-date reference manual is an essential book for those working in the field and for scientists in other disciplines. It represents a major information resource on the fascinating and fast-moving field of epigenetics.

Progress In Nucleic Acid Research And Molecular Biology

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Publisher: Academic Press
ISBN: 9780080863405
Size: 60.86 MB
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Progress In Nucleic Acid Research And Molecular Biology by


Original Title: Progress In Nucleic Acid Research And Molecular Biology

Praise for the Serial: "Full of interest not only for the molecular biologist - for whom the numerous references will be invaluable - but will also appeal to a much wider circle of biologists, and in fact to all those who are concerned with the living cell." --British Medical Journal Provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology Contributions from leaders in their fields Abundant references

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