Optimization In Medicine

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Author: Carlos J. S. Alves
Publisher: Springer Science & Business Media
ISBN: 9780387732992
Size: 38.83 MB
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Optimization In Medicine by Carlos J. S. Alves


Original Title: Optimization In Medicine

This volume presents a wide range of medical applications that can utilize mathematical computing. This work grew out of a workshop on optimization which was held during the 2005 CIM Thematic Term on Optimization in Coimbra, Portugal. It provides an overview of the state-of-the-art in optimization in medicine and will serve as an excellent reference for researchers in the medical computing community and for those working in applied mathematics and optimization.

Optimization In Medicine And Biology

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Author: Gino J. Lim
Publisher: CRC Press
ISBN: 9780849305696
Size: 41.52 MB
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Optimization In Medicine And Biology by Gino J. Lim


Original Title: Optimization In Medicine And Biology

Thanks to recent advancements, optimization is now recognized as a crucial component in research and decision-making across a number of fields. Through optimization, scientists have made tremendous advances in cancer treatment planning, disease control, and drug development, as well as in sequencing DNA, and identifying protein structures. Optimization in Medicine and Biology provides researchers with a comprehensive, single-source reference that will enable them to apply the very latest optimization techniques to their work. With contributions from pioneering international experts this volume integrates strong foundational theory, good modeling techniques, and efficient and robust algorithms with relevant applications Divided into two sections, the first begins with mathematical programming techniques for medical decision making processes and demonstrates their application to optimizing pediatric vaccine formularies, kidney paired donation, and the cost-effectiveness of HIV programs. It also presents recent advances in cancer treatment planning models and solution algorithms, including three-dimensional conventional conformal radiation therapy (3DCRT), intensity modulated radiation therapy (IMRT), tomotherapy, and proton therapy. Part two focuses on optimization in biology and discusses computational algorithms for genomic analysis; probe design and selection, properties of probes, and various algorithms and software packages to aid in probe selection and design. Subsequent chapters introduce a new dihedral angle measure for protein secondary prediction, and an optimization approach for tumor virotherapy with recombinant measles viruses. The editors include a short tutorial appendix on Integer Programming (IP). Highlighting the most recent advances in optimization techniques for solving complex problems in medical research, this book facilitates strong collaborative environments among optimization researchers and medical professionals for future medical research.

Handbook Of Optimization In Medicine

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Author: Panos M. Pardalos
Publisher: Springer Science & Business Media
ISBN: 0387097708
Size: 35.33 MB
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Handbook Of Optimization In Medicine by Panos M. Pardalos


Original Title: Handbook Of Optimization In Medicine

Handbook of Optimization in Medicine is devoted to examining the dramatic increase in the application of effective optimization techniques to the delivery of health care. The articles, written by experts, focus on models and algorithms that have led to more efficient and sophisticated treatments of patients. Topics covered include: optimization in medical imaging, classification and data mining with medical applications, treatment of epilepsy and other brain disorders, treatment of head-and-neck, prostate, and other cancers using conventional conformal and intensity-modulated radiation therapy as well as proton therapy, treatment selection for breast cancer based on new classification schemes, optimization for the genome project, optimal timing of organ transplants.

Applications Of Intelligent Optimization In Biology And Medicine

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Author: Aboul-Ella Hassanien
Publisher: Springer
ISBN: 3319212125
Size: 38.53 MB
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Applications Of Intelligent Optimization In Biology And Medicine by Aboul-Ella Hassanien


Original Title: Applications Of Intelligent Optimization In Biology And Medicine

This volume provides updated, in-depth material on the application of intelligent optimization in biology and medicine. The aim of the book is to present solutions to the challenges and problems facing biology and medicine applications. This Volume comprises of 13 chapters, including an overview chapter, providing an up-to-date and state-of-the research on the application of intelligent optimization for bioinformatics applications, DNA based Steganography, a modified Particle Swarm Optimization Algorithm for Solving Capacitated Maximal Covering Location Problem in Healthcare Systems, Optimization Methods for Medical Image Super Resolution Reconstruction and breast cancer classification. Moreover, some chapters that describe several bio-inspired approaches in MEDLINE Text Mining, DNA-Binding Proteins and Classes, Optimized Tumor Breast Cancer Classification using Combining Random Subspace and Static Classifiers Selection Paradigms, and Dental Image Registration. The book will be a useful compendium for a broad range of readers—from students of undergraduate to postgraduate levels and also for researchers, professionals, etc.—who wish to enrich their knowledge on Intelligent Optimization in Biology and Medicine and applications with one single book.

Motion Planning In Medicine Optimization And Simulation Algorithms For Image Guided Procedures

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Author: Ron Alterovitz
Publisher: Springer
ISBN: 3540692592
Size: 68.82 MB
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Motion Planning In Medicine Optimization And Simulation Algorithms For Image Guided Procedures by Ron Alterovitz


Original Title: Motion Planning In Medicine Optimization And Simulation Algorithms For Image Guided Procedures

Written by Ron Alterovitz and Ken Goldberg, this monograph combines ideas from robotics, physically-based modeling, and operations research to develop new motion planning and optimization algorithms for image-guided medical procedures.

Motion Planning In Medicine Optimization And Simulation Algorithms For Image Guided Procedures

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Author: Ron Alterovitz
Publisher: Springer Science & Business Media
ISBN: 3540692576
Size: 29.91 MB
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Motion Planning In Medicine Optimization And Simulation Algorithms For Image Guided Procedures by Ron Alterovitz


Original Title: Motion Planning In Medicine Optimization And Simulation Algorithms For Image Guided Procedures

Written by Ron Alterovitz and Ken Goldberg, this monograph combines ideas from robotics, physically-based modeling, and operations research to develop new motion planning and optimization algorithms for image-guided medical procedures.

Optimization In Drug Discovery

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Author: Zhengyin Yan
Publisher: Springer Science & Business Media
ISBN: 1592598005
Size: 11.88 MB
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Optimization In Drug Discovery by Zhengyin Yan


Original Title: Optimization In Drug Discovery

Recent reports of drug attrition rates have revealed that a significant number of drug candidates fail in the later stage of clinical development due to absorption, distribution, metabolism, elimination and toxicity issues. Lead optimization in drug discovery, a process of attempting to uncover and correct these defects, is highly beneficial in lowering the cost and time to develop therapeutic drugs by reducing drug candidate failures in development. This book provides the assays utilized in drug discovery to rapidly screen for compounds with favorable drug-like properties. A total of 25 chapters, contributed by many experts in the field, cover a wide spectrum of subjects including physicochemical properties, absorption, plasma binding, metabolism, drug interactions, and toxicity, making this an essential book for all pharmacologists and pharmaceutical scientists.

Nutrient Timing

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Author: Chad M. Kerksick
Publisher: CRC Press
ISBN: 1439838909
Size: 40.20 MB
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Nutrient Timing by Chad M. Kerksick


Original Title: Nutrient Timing

Sports nutrition has evolved beyond what to eat and how much to eat to now include the question of when to eat. A hot topic in sports nutrition, nutrient timing is a dietary concept that takes into account time as a missing dimension in athletic performance and recovery. Not only is the consumption of nutrients in ideal amounts and proportions important, but the timing with which they are administered is also of prime importance—the right nutrients at the ideal time to affect performance and muscular growth. Nutrient Timing: Metabolic Optimization for Health, Performance, and Recovery presents the most authoritative text to date that scientifically examines the contemporary topic of nutrient timing. Worldwide research continues to rapidly explore the metabolic impact of nutrient timing and how its proper application may help to improve performance. With contributions from scientists and practitioners in the field, this book gathers the latest evidence-based information on this cutting-edge area. The chapters cover macronutrients—carbohydrates, proteins, and lipids—and their role in sporting activity, as well as an examination of vitamins and minerals. The core of the book focuses on pre-exercise, mid-exercise, and post-exercise considerations for both resistance and aerobically mediated activity. Using the models presented, individuals may improve performance, promote optimal adaptations to training, maximize recovery, and facilitate healthy interactions with their environment. The final chapters of the book describe future concepts in nutrient timing, including the impact of protein source in the context of timing, how nutrient timing can fit in with a comprehensive recovery program, and the application of the ideas discussed in unique populations such as the aged, the military, and populations interested in weight loss. This text provides solid data from the scientists themselves, giving researchers, teachers, coaches, and medical and health care professionals the necessary information they need to accurately and effectively determine how nutrients can impact certain outcomes and, most importantly, how to practically apply this knowledge.

Drug Like Properties Concepts Structure Design And Methods

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Author: Li Di
Publisher: Elsevier
ISBN: 0080557619
Size: 29.57 MB
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Drug Like Properties Concepts Structure Design And Methods by Li Di


Original Title: Drug Like Properties Concepts Structure Design And Methods

Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its increasing importance in advancing high quality candidates to clinical studies and the processes of drug discovery. If the properties are weak, the candidate will have a high risk of failure or be less desirable as a drug product. This book is a tool and resource for scientists engaged in, or preparing for, the selection and optimization process. The authors describe how properties affect in vivo pharmacological activity and impact in vitro assays. Individual drug-like properties are discussed from a practical point of view, such as solubility, permeability and metabolic stability, with regard to fundamental understanding, applications of property data in drug discovery and examples of structural modifications that have achieved improved property performance. The authors also review various methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties. * Serves as an essential working handbook aimed at scientists and students in medicinal chemistry * Provides practical, step-by-step guidance on property fundamentals, effects, structure-property relationships, and structure modification strategies * Discusses improvements in pharmacokinetics from a practical chemist's standpoint

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