Download Read Online Peptides book
Author: Bernd Gutte
Publisher: Elsevier
ISBN: 9780080538594
Size: 80.97 MB
Format: PDF, ePub
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Peptides by Bernd Gutte

Original Title: Peptides

In recent years, research has shown the importance of peptides in neuroscience, immunology, and cell biology. Active research programs worldwide are now engaged in developing peptide-based drugs and vaccines using modification of natural peptides and proteins, design of artificial peptides and peptide mimetics, and screening of peptide and phage libraries. In this comprehensive book, the authors discuss peptide synthesis and application within the context of their increasing importance to the pharmaceutical industry. Peptides: Synthesis, Structures, and Applications explores the broad growth of information in modern peptide synthetic methods and the structure-activity relationships of synthetic polypeptides. The history of peptide chemistry Amide formation, deprotection, and disulfide formation in peptide synthesis Solid-phase peptide synthesis a-helix formation by peptides in water Stability and dynamics of peptide conformation An overview of structure-function studies of peptide hormones Neuropeptides:peptide and nonpeptide analogs Reversible inhibitors of serine proteinases Design of polypeptides Current capabilities and future possibilities of soluble chemical combinatorial libraries Epitope mapping with peptides Synthesis and applications of branched peptides in immunological methods and vaccines

Chemical Approaches To The Synthesis Of Peptides And Proteins

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Author: Paul Lloyd-Williams
Publisher: CRC Press
ISBN: 9780849391422
Size: 76.33 MB
Format: PDF, Kindle
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Chemical Approaches To The Synthesis Of Peptides And Proteins by Paul Lloyd-Williams

Original Title: Chemical Approaches To The Synthesis Of Peptides And Proteins

Organic chemists working on the synthesis of natural products have long found a special challenge in the preparation of peptides and proteins. However, more reliable, more efficient synthetic preparation methods have been developed in recent years. This reference evaluates the most important synthesis methods available today, and also considers methods that show promise for future applications. This text describes the state of the art in efficient synthetic methods for the synthesis of both natural and artificial large peptide and protein molecules. Subjects include an introduction to basic topics, linear solid-phase synthesis of peptides, peptide synthesis in solution, convergent solid-phase synthesis, methods for the synthesis of branched peptides, formation of disulfide bridges, and more. The book emphasizes strategies and tactics that must be considered for the successful synthesis of peptides.

Nitroazoles Synthesis Structure And Applications

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Author: Lyudmila Larina
Publisher: Springer Science & Business Media
ISBN: 9780387980706
Size: 19.99 MB
Format: PDF, ePub
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Nitroazoles Synthesis Structure And Applications by Lyudmila Larina

Original Title: Nitroazoles Synthesis Structure And Applications

This volume is devoted to the synthesis, application, structure, and physicochemical properties of nitroazoles (five-membered aromatic compounds). The book is unique in providing the first comprehensive treatment of nitroazoles.

Synthetic Peptides

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Author: Gregory A. Grant
Publisher: Oxford University Press on Demand
ISBN: 0195132610
Size: 72.44 MB
Format: PDF, Docs
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Synthetic Peptides by Gregory A. Grant

Original Title: Synthetic Peptides

The first synthetic peptides were produces a century ago. In the ensuing period, they have developed as valuable research tools that are readily available to all researchers. However, since most reasearchers do not make their own peptides, they are often unfamiliar with not only the synthetic chemistry, but also with important and useful aspects of design, analysis, handling, and applications. This volume is written by experts in the field who provide detailed descriptions as well as practical advice for producing and using synthetic peptides. Chapters cover peptide design considerations, the synthetic chemistry, the evaluation of the synthetic product,and the modern applications of synthetic peptides. (Midwest).

Peptide Antibiotics

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Author: Christopher Dutton
Publisher: CRC Press
ISBN: 9780203910801
Size: 21.87 MB
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Peptide Antibiotics by Christopher Dutton

Original Title: Peptide Antibiotics

This reference summarizes the latest research on the structure, function, and design of synthetic and natural peptide antibiotics, describing practical applications of these compounds in food preservation and packaging, and in the prevention and treatment of infectious diseases by direct anti-bacterial action and as part of the adaptive immune response. Peptide Antibiotics discusses these unique compounds and their many and exciting applications, including: the distribution and classification of diverse antimicrobial peptides throughout nature the role in host defense of mucosal surface peptide antibiotics such as defensins and cathepsins the biosynthesis of lanthionine-containing antibiotics including nisin, epidermin, and mersacidin the genetic basis determining the production of bacterial peptide antibiotics the potential commercial use of magainin, nisin, and lacticin peptides as anti-infective agents the use of nisin as a commercial food preservative With contributions from 19 world-renowned experts in the field, Peptide Antibiotics is an indispensable source of information for pharmaceutical scientists, medicinal and organic chemists and biochemists, microbiologists, infectious disease specialists, molecular biologists, and upper-level undergraduate and graduate students in these disciplines.

Peptide And Protein Design For Biopharmaceutical Applications

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Author: Knud Jensen
Publisher: John Wiley & Sons
ISBN: 9780470749715
Size: 78.11 MB
Format: PDF, ePub
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Peptide And Protein Design For Biopharmaceutical Applications by Knud Jensen

Original Title: Peptide And Protein Design For Biopharmaceutical Applications

Peptides serve as effective drugs in the clinic today. However the inherent drawbacks of peptide structures can limit their efficacy as drugs. To overcome this researchers are developing new methods to create ‘tailor-made’ peptides and proteins with improved pharmacological properties. Design of Peptides and Proteins provides an overview of the experimental and computational methods for peptide and protein design, with an emphasis on specific applications for therapeutics and biomedical research. Topics covered include: Computer modeling of peptides and proteins Peptidomimetics Design and synthesis of cyclic peptides Carbohydrates in peptide and protein design De novo design of peptides and proteins Medical development applications An extended case study – the design of insulin variants Design of Peptides and Proteins presents the state-of-the-art of this exciting approach for therapeutics, with contributions from international experts. It is an essential resource for academic and industrial scientists in the fields of peptide and protein drug design, biomedicine, biochemistry, biophysics, molecular modelling, synthetic organic chemistry and medicinal/pharmaceutical chemistry.

Solid Phase Synthesis

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Author: Fernando Albericio
Publisher: CRC Press
ISBN: 9780824703592
Size: 51.44 MB
Format: PDF, Kindle
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Solid Phase Synthesis by Fernando Albericio

Original Title: Solid Phase Synthesis

This volume provides the information needed to synthesize peptides by solid-phase synthesis (SPS) - employing polymeric support (resins), anchoring linkages (handles), coupling reagents (activators), and protection schemes. It presents strategies for creating a wide variety of compounds for drug discovery and analyzes peptides, DNA, carbohydrates, conjugates of biomolecules, and small molecules.

Protein Engineering By Semisynthesis

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Author: Carmichael J.A. Wallace
Publisher: CRC Press
ISBN: 9780849347276
Size: 42.87 MB
Format: PDF, ePub, Mobi
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Protein Engineering By Semisynthesis by Carmichael J.A. Wallace

Original Title: Protein Engineering By Semisynthesis

As genomics gives way to proteomics as the focus of scientific imagination in the biological sciences, more emphasis will be placed on the technology and interpretation of protein engineering experiments. Protein engineers will become increasingly sophisticated in the questions that they pose and demanding of the tools available to change protein structure. The optimal way to introduce non-coded amino acids for mechanistic studies, or site-specific reporter atoms for spectroscopic structural biology, is by protein semisynthesis. In Protein Engineering by Semisynthesis, the leading practitioners of the method cover their individual protein of expertise forming a comprehensive illustration of the various methods developed. By covering the most recent philosophical and methodological approaches and developments of semisynthesis and peptide synthesis to date, this book provides further understanding of the principles of protein structure-function relationships gained from semisynthetic analog in addition to providing a comprehensive and comprehensible laboratory guide. This book focuses on recent developments which synergistically combine chemical and molecular biological techniques that have made semisynthetic manipulations much easier to undertake. Features

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