Prostaglandins And Arachidonate Metabolites Volume 86 Prostglandins And Arachidonate Metabolites

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Author: William E. M. Lands
Publisher: Methods in Enzymology
ISBN: 9780121819866
Size: 48.75 MB
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Prostaglandins And Arachidonate Metabolites Volume 86 Prostglandins And Arachidonate Metabolites by William E. M. Lands


Original Title: Prostaglandins And Arachidonate Metabolites Volume 86 Prostglandins And Arachidonate Metabolites

The critically acclaimed laboratory standard, Methods in Enzymology, is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. The series contains much material still relevant today - truly an essential publication for researchers in all fields of life sciences.

Prostaglandins In Cancer Research

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Author: Enrico Garaci
Publisher: Springer Science & Business Media
ISBN: 364271904X
Size: 45.95 MB
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Prostaglandins In Cancer Research by Enrico Garaci


Original Title: Prostaglandins In Cancer Research

Arachidonic acid metabolites are known to playa regulatory role in a number of biological systems, in which they function as microenviron mental hormones and intracellular signal mediators. One of the most exciting areas of research of these compounds is the one that studies the relationship between prostaglandins and tumor cell growth and function. In the last few years there has been an extraordinary evolution of data on prostaglandins (and related compounds) and cancer. This vol ume is based on papers presented at the 1986 International Confer ence on Prostaglandins and Cancer organized by the Italian National Research Council and the II University of Rome, and held in Rome, Italy, in June, 1986. This Conference brought together oncologists and specialists in the areas of prostaglandin chemistry, biochemistry, pharmacology, physiology, cellular and molecular biology to overview the actual state of knowledge on the role of eicosanoids in cancer and to focus on the key questions that need to be answered. The picture that comes out of this book describes a very complicated network of interactions between arachidonic acid metabolites and different as pects of the complex phenomenon "cancer". Eicosanoids participate in carcinogenesis initiation and promotion, and their relationship with tumor promoters and growth factors is well established. During cancer growth, different prostaglandins can have different roles in the regulation of cell proliferation and differentiation and in metastasis formation; meanwhile evidence is accumulating for a pos sible use of some of these compounds as antineoplastic agents.

Recent Advances In Prostaglandin Thromboxane And Leukotriene Research

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Author: Helmut Sinzinger
Publisher: Springer Science & Business Media
ISBN: 9780306457760
Size: 68.83 MB
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Recent Advances In Prostaglandin Thromboxane And Leukotriene Research by Helmut Sinzinger


Original Title: Recent Advances In Prostaglandin Thromboxane And Leukotriene Research

One hundred papers treat advances in research of the effects and uses of prostaglandins, thromboxanes, and leukotrienes in such medical fields as organ transplantation, male erectile dysfunction, amniotic fluid infection and labour, renal function, anti-inflammatory drugs, allergic and aspirin-intol

Prostaglandin And Lipid Metabolism In Radiation Injury

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Author: Thomas L., Jr. Walden
Publisher: Springer Science & Business Media
ISBN: 1468454579
Size: 44.68 MB
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Prostaglandin And Lipid Metabolism In Radiation Injury by Thomas L., Jr. Walden


Original Title: Prostaglandin And Lipid Metabolism In Radiation Injury

This volume contains the proceedings of the International Conference on Prostaglandins and Lipid Metabolism in Radiation Injury held in Rockville, Maryland, on October 2-3, 1986. Over 200 persons from eight countries attended the program, which consisted of 24 oral presentations and 38 poster presentations. Forty-two of those presentations have been included in this volume. The conference was sponsored by the Armed Forces Radiobiology Research Institute, located in Bethesda, Maryland. The effects of radiation on lipid synthesis and membrane damage are aptly summarized in the first five chapters. These chapters describe the effects of radiation on lipid peroxidation of model membranes, and the role of lipid composition in mammalian cell death and in bacterial radio- and thermosensitivity. In bacteria, lipid peroxidation is not essential for radiation-induced cell death. One of the key points of the conference was the paradoxical nature of the radiobiology of eicosanoids. On the one hand, eicosanoids are mediators of damage; on the other, they are radioprotective agents. It is clear from the literature and from the data presented at the conference that both of these properties may also be observed as a consequence of radiotherapy. Some studies indicate that nonsteroidal anti-inflammatory drugs may minimize or prevent certain radiation induced damage, but other studies show no positive effect.

Arachidonic Acid Metabolism And Tumor Promotion

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Author: Susan M. Fischer
Publisher: Springer
ISBN:
Size: 30.73 MB
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Arachidonic Acid Metabolism And Tumor Promotion by Susan M. Fischer


Original Title: Arachidonic Acid Metabolism And Tumor Promotion

Prostaglandins, Leukotrienes, and Cancer is a multi-volume series that will focus on an emerging area of cancer research. In 1968, R.H. Williams first reported that elevated prostaglandin levels are present in human medullary car cinoma. Since that time, the concept that arachidonic acid metabolites may be in volved in cancer has expanded to include every aspect of the disease from cell transformation through metastasis. Prostaglandins and leukotrienes are generic terms used to describe a family of bioactive lipids produced from unsaturated fatty acids (principally from and lipoxygenase pathways, respec arachidonic acid) via the cyclooxygenase tively. Cyclooxygenase products consist of diverse products such as prosta glandin E2 (POE), prostacyclin (POI) and thromboxane A2 (TXA), whereas 2 2 2 lipoxygenase products consist of hydroperoxy fatty acids and mono-, di- and tri-hydroxy acids including leukotrienes. The precursor fatty acids for the cyclooxygenase and lipoxygenase pathways are present in cellular phospholipids. This finding established an important control point in their biosynthesis-the release of substrate. This occurs in response to numerous stimuli that act at the cell surface. Dr. Bengt Samuelsson's extensive study of the metabolism of pros taglandins indicated that they are rapidly inactivated on a single pass through pulmonary circulation. Thus, they cannot act as circulating hormones and appear to be made on demand in or in the vicinity of target tissues leading to the concept that prostaglandins are local hormones or autocoids.

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