Protein Adaptations And Signal Transduction

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Author: K.B. Storey
Publisher: Elsevier
ISBN: 9780080539966
Size: 75.55 MB
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Protein Adaptations And Signal Transduction by K.B. Storey


Original Title: Protein Adaptations And Signal Transduction

This volume of Cell and Molecular Responses to Stress has two broad themes: an examination of selected protein adaptations that support stress tolerance and an analysis of signal transduction systems, those critical links between the perception of stress and the activation of the coordinated metabolic responses that ensure survival. Several chapters deal with adaptive responses to environmental cold temperature and highlight novel advances in mammalian hibernation, low temperature enzyme function, cold-shock and antifreeze proteins, and freezing survival. Other chapters stretch out to explore biochemical responses to diverse stresses including water stress, mechanical stress, nutrient availability, oxygen limitation and oxidative stress. The integral roles of protein kinases, transcription factors, oxygen free radicals, and oxygen-sensitive ion channels in the detection and mediation of stress responses are explored. The multiplicity of responses is emphasized and shows us the vast potential of cells and organisms to respond to innumerable stresses, great and small, and the regulatory principles and mechanisms that are used to allow life to adapt and endure in every environment on Earth. Featuring: A discussion of new advances in understanding protein adaptations that support organismal survival of stress. State-of-the-art analysis of key components of cellular signal transduction pathways including protein kinases and calcium and the control, integration and action of signal transduction pathways in response to stresses including mechanical stress, nutrient availability, oxidative stress.

Histidine Kinases In Signal Transduction

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Author: Masayori Inouye
Publisher: Elsevier
ISBN: 0080534015
Size: 39.33 MB
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Histidine Kinases In Signal Transduction by Masayori Inouye


Original Title: Histidine Kinases In Signal Transduction

Living cells are constantly sensing environmental changes, and their abilities to sense these changes and adapt to them are essential for their survival. In bacteria, histidine kinases are the major sensors for these environmental stresses, enabling cells to adapt to new growth conditions. Written by leading experts in the field, this book provides an up-to-date and comprehensive review on the structure and function of histidine kinases. It also provides extensive information on the physiological roles of histidine kinases in bacteria and eukaryotes. An an essential reference for cell biologists, microbiologists, molecular biologists, and biochemists interested in signal transduction. Experimental biologists and pharmacologists studying signal transduction systems in living organisms will also find it a valuable research tool. The first comprehensive book on the roles of histidine kinases in cells 23 in-depth chapters written by leading experts in the field Describes the most recent advances in the field of signal transduction

Genetics And Molecular Biology Of Muscle Adaptation

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Author: Neil Spurway
Publisher: Elsevier Health Sciences
ISBN: 0443100772
Size: 36.61 MB
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Genetics And Molecular Biology Of Muscle Adaptation by Neil Spurway


Original Title: Genetics And Molecular Biology Of Muscle Adaptation

This title is directed primarily towards health care professionals outside of the United States. It starts with the origin of life and ends with the mechanisms that make muscles adapt to different forms of training. In between, it considers how evidence has been obtained about the extent of genetic influence on human capacities, how muscles and their fibres are studied for general properties and individual differences, and how molecular biological techniques have been combined with physiological ones to produce the new discipline of molecular exercise physiology. This is the first book on such topics written specifically for modules in exercise and sport science at final year Hons BSc and taught MSc levels.

Protein Adaptation In Extremophiles

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Author: Khawar Sohail Siddiqui
Publisher: Nova Publishers
ISBN: 9781604560190
Size: 15.50 MB
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Protein Adaptation In Extremophiles by Khawar Sohail Siddiqui


Original Title: Protein Adaptation In Extremophiles

Life has evolved in an extraordinary way to deal with the most extreme physical and chemical conditions. Extremophilic (extreme-loving) organisms have been found in the superheated waters of deep ocean vents or the hypersaline and cold lakes of Antarctica and indeed often require the extreme conditions of their habitat to survive and thrive. The cellular machinery of extremophiles has developed unique adaptation strategies to effectively function in their given environment. Much scientific attention has focussed on the adaptation of proteins as they have both structural and catalytic functions and hence play key roles in all cellular processes. Moreover, their ability to perform in or withstand extreme physical and chemical conditions has made extremophilic proteins attractive bio-catalysts for a range of industrial and biotechnological applications. This novel and significant book comprehensively summarises our current understanding regarding the structure-function-stability relationship of extremophilic proteins. Leading experts in the field extensively review and comment on the adaptation of proteins to the whole spectrum of physical and chemical extremes. This book represents an important and indispensable reference for students, teachers and researchers with interest or activities in the fascinating area of extremophiles.

Biochemical Adaptation

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Author: Peter W. Hochachka
Publisher: Oxford University Press
ISBN: 0195353676
Size: 24.98 MB
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Biochemical Adaptation by Peter W. Hochachka


Original Title: Biochemical Adaptation

The study of biochemical adaption provides fascinating insights into how organisms "work" and how they evolve to sustain physiological function under a vast array of environmental conditions. This book describes how the abilities of organisms to thrive in widely different environments derive from two fundamental classes of biochemical adaptions: modifications of core biochemical processes that allow a common set of physiological functions to be conserved, and "inventions" of new biochemical traits that allow entry into novel habitats. Biochemical Adaptation: Mechanisms and Process in Physiological Evolution asks two primary questions. First, how have the core biochemical systems found in all species been adaptively modified to allow the same fundamental types of physiological processes to be sustained throughout the wide range of habitat conditions found in the biosphere? Second, through what types of genetic and biochemical processes have new physiological functions been fabricated? The primary audience for this book is faculty, senior undergraduates, and graduate students in environmental biology, comparative physiology, and marine biology. Other likely readers include workers in governmental laboratories concerned with environmental issues, medical students interested in some elements of the book, and medical researchers.

Molecular Exercise Physiology

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Author: Henning Wackerhage
Publisher: Routledge
ISBN: 1136477039
Size: 18.41 MB
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Molecular Exercise Physiology by Henning Wackerhage


Original Title: Molecular Exercise Physiology

Molecular Exercise Physiology: An Introduction is the first student-friendly textbook to be published on this key topic in contemporary sport and exercise science. It introduces sport and exercise genetics and the molecular mechanisms by which exercise causes adaptation. The text is linked to real life sport and exercise science situations such as ‘what makes people good at distance running?’, ‘what DNA sequence variations code for a high muscle mass?’ or ‘by what mechanisms does exercise improve type2 diabetes?’ The book includes a full range of useful features, such as summaries, definitions of key terms, guides to further reading, review questions, personal comments by molecular exercise pioneers (Booth, Bouchard) and leading research in the field, as well as descriptions of research methods. A companion website offers interactive and downloadable resources for both student and lecturers. Structured around central themes in sport and exercise science, such as nutrition, endurance training, resistance training, exercise & chronic disease and ageing, this book is the perfect foundation around which to build a complete upper-level undergraduate or postgraduate course on molecular exercise physiology.

Delayed Preconditioning And Adaptive Cardioprotection

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Author: G.F. Baxter
Publisher: Springer Science & Business Media
ISBN: 9401153124
Size: 50.10 MB
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Delayed Preconditioning And Adaptive Cardioprotection by G.F. Baxter


Original Title: Delayed Preconditioning And Adaptive Cardioprotection

Interest in the ability of myocardium to adapt to ischaemic stress has continued to grow since the discovery of ischaemic preconditioning in 1986. In 1993, two reports heralded the recognition of a delayed preconditioning response in the heart, now commonly known as the `second window' of protection. Since then, a number of studies have described the ability of delayed preconditioning and related adaptive phenomena to protect against a variety of pathologies in the ischaemic and reperfused myocardium. Our understanding of the cellular mechanisms of sub-acute adaptive cardioprotection has advanced considerably during this period. This compilation of state-of-the-art reviews by those who have made significant contributions to this field provides detailed and critical analysis of this research, from molecular basis to potential clinical relevance. The book aims to provide an authoritative, comprehensive and thoroughly up-to-date overview for scientists and clinicians engaged in, or observing, this rapidly-developing area of heart research. It will also be of interest to those engaged in research on other tissues where ischaemia-reperfusion pathology is of major concern.

Signal Transduction

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Author: B. D. Gomperts
Publisher: Gulf Professional Publishing
ISBN: 9780122896316
Size: 37.52 MB
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Signal Transduction by B. D. Gomperts


Original Title: Signal Transduction

Signal Transduction is a well-illustrated, coherent look at cellular signaling processes. Beginning with the basics, it explains how cells respond to external cues, hormones, growth factors, cytokines, cell surfaces, etc., and then shows how these inputs are integrated and coordinated. The extensive color artwork provides the reader with a clearer comprehension of key topics, and margin notes are incorporated to highlight milestones in the evolution of signal transduction. This book serves as an invaluable resource for advanced undergraduates, graduate researchers, and established scientists working in cell biology, pharmacology, immunology, and related fields. Key Features *Coherent, precise text providing insight in depth to a subject that is central to cell biology and fundamental to many areas of biomedicine * Extensive conceptual colour artwork assists with the comprehension of key topics * Extensive referencing provides an invaluable link to the core and historical literature * Margin notes highlighting milestones in the evolution of our understanding of signalling mechanisms

Adaptation To Life At High Salt Concentrations In Archaea Bacteria And Eukarya

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Author: Nina Gunde-Cimerman
Publisher: Springer Science & Business Media
ISBN: 1402036337
Size: 62.60 MB
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Adaptation To Life At High Salt Concentrations In Archaea Bacteria And Eukarya by Nina Gunde-Cimerman


Original Title: Adaptation To Life At High Salt Concentrations In Archaea Bacteria And Eukarya

Salt is an essential requirement of life. Already from ancient times (e. g. , see the books of the Bible) its importance in human life has been known. For example, salt symbolizes destruction (as in Sodom and Gomorra), but on the other hand it has been an ingredient of every sacrifice during the Holy Temple periods. Microbial life in concentrated salt solutions has fascinated scientists since its discovery. Recently there have been several international meetings and books devoted entirely to halophiles. This book includes the proceedings of the “Halophiles 2004” conference held in Ljubljana, Slovenia, in September 2004 (www. u- lj. si/~bfbhaloph/index. html). This meeting was attended by 120 participants from 25 countries. The editors have selected presentations given at the meeting for this volume, and have also invited a number of contributions from experts who had not been present in Ljubljana. This book complements “Halophilic Microorganisms”, edited by A. Ventosa and published by Springer-Verlag (2004), “Halophilic Microorganism and their Environments” by A. Oren (2002), published by Kluwer Academic Publishers as volume 5 of “Cellular Origins, Life in Extreme Habitats and Astrobiology” (COLE), and “Microbiology and Biogeochemistry of Hypersaline Environments” edited by A. Oren, and published by CRC Press, Boca Raton (1999). Salt-loving (halophilic) microorganisms grow in salt solutions above seawater salinity (~3. 5% salt) up to saturation ranges (i. e. , around 35% salt). High concentrations of salt occur in natural environments (e. g.

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