Extracellular Matrix

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Author: Mark A. Zern
Publisher: CRC Press
ISBN: 9780824788308
Size: 61.52 MB
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Extracellular Matrix by Mark A. Zern


Original Title: Extracellular Matrix

Describing state-of-the-art research techniques for clinicians and introducing important clinical perspectives for basic scientists, this reference examines some significant areas of investigation into the biology of the extracellular matrix and its implications in human pathophysiology.;Focusing on the liver and providing a broad survey of the latest information available, Extracellular Matrix: discusses a wide range of models and organ systems; presents pathophysiological studies emphasizing hepatic disease, particularly the development of fibrosis and cirrhosis; furnishes structure and function analyses of the major extracellular matric components, including collagens, laminin, fibronectin, and proteoglycans; delineates the mechanisms leading to increased depositions of the matrix proteins during hepatic fibrogenesis; details new therapeutic approaches to liver disease; and more.;With authoritative contributions from more than 40 leading international experts representing five countries, Extracellular Matrix should be a useful reference for all scientists interested in matrix biology, chemistry, or pathobiology, especially gastroenterologists, hepatologists, pathologists, and graduate and medical school students in these disciplines.

Mitochondrial Biogenesis And Genetics

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Author: Giuseppe Attardi
Publisher: Gulf Professional Publishing
ISBN: 9780121821654
Size: 73.54 MB
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Mitochondrial Biogenesis And Genetics by Giuseppe Attardi


Original Title: Mitochondrial Biogenesis And Genetics

The critically acclaimed laboratory standard for forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerlyawaited, frequently consulted, and praised by researchers and reviewers alike. More than 260 volumes have been published (all of them still in print) and much of the material is relevant even today--truly an essential publication for researchers in all fields of life sciences. Key Features * This volume covers methodology used in * Mitochondrial gene expression * Mitochondrial genetics and gene manipulation * Mitochondrial diseases and aging

Combinatorial Chemistry

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Author: John Abelson
Publisher: Elsevier
ISBN: 9780121821685
Size: 42.80 MB
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Combinatorial Chemistry by John Abelson


Original Title: Combinatorial Chemistry

The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. More than 260 volumes have been published (all of them still in print) and much of the material is relevant even today--truly an essential publication for researchers in all fields of life sciences. Key Features * Phage display libraries * Repression fusion proteins * Polysome libraries * Peptide libraries * Nucleic acid libraries * Other small molecule libraries

Nitric Oxide

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Author: Lester Packer
Publisher: Gulf Professional Publishing
ISBN: 9780121821692
Size: 19.30 MB
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Nitric Oxide by Lester Packer


Original Title: Nitric Oxide

Nitric oxide, recently named"Molecule of the Year"by the journal Science, impinges on a wide range of fields in biological research, particularly in the areas of biomedicine and cell and organismal biology, as well as in fundamental chemistry. This volume and its companion Volume 269 highlight the most current and up-to-date methods used to research the physiology and toxicity of nitric oxide in cellular and organismal systems. It will be a valuable resourcefor the experienced researcher as well as for those newly entering the field. Generation, detection, and characterization of biological and chemical sources of nitric oxide Biochemistry and molecular biology of enzymes and proteins associated with nitric oxide metabolism

Aqueous Two Phase Systems

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Author: Harry Walter
Publisher: Elsevier
ISBN: 9780121821296
Size: 56.72 MB
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Aqueous Two Phase Systems by Harry Walter


Original Title: Aqueous Two Phase Systems

This volume of Methods in Enzymology represents the sole collection of separation methods based on aqueous two-phase systems. It includes procedures for the isolation of proteins, especially enzymes, nucleic acids, cell membranes, and organelles, as well as for the separation and study of cells. Key Features * Use of affinity partitioning for enzyme purification * Separation and study of cells * Isolation of plasma membranes * Large scale biotechnical use

Serpin Structure And Evolution

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Author: James C. Whisstock
Publisher: Academic Press
ISBN: 0123859506
Size: 23.17 MB
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Serpin Structure And Evolution by James C. Whisstock


Original Title: Serpin Structure And Evolution

The challenge for the field is to elucidate the role of each particular serpin in its own niche, and this will typically require examination of structure, tissue distribution and cellular localization, identification of partners or targets, and assessment of physiological significance via forward or reverse genetics. Examples of these approaches will be found within these pages. What then are the "big questions" or achievements remaining in serpin research? We would nominate (in no particular order) the precise physiological mechanism of serpin polymerization and associated cytotoxicity, the roles of noninhibitory serpins and the contribution of conformational change to their function, and the development of additional targeted antiserpin therapeutics. Finally, as we move into the era of the 1000 genomes project and the routine sequencing of human genomes for medical purposes, we expect that a greater number of serpin mutations will be associated with a wide range of human diseases. The next generation of serpin researchers will make great inroads into all these problems

Rna Ligand Interactions Part A Structural Biology Methods

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Author:
Publisher: Elsevier
ISBN: 0080496741
Size: 49.97 MB
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Rna Ligand Interactions Part A Structural Biology Methods by


Original Title: Rna Ligand Interactions Part A Structural Biology Methods

RNA-Ligand Interactions, Part A focuses on structural biology methods. Major topics covered include semisynthetic methodologies (RNA synthetic methods and derivatization of RNA); RNA structure determination (X-ray crystallography, NMR, EM); techniques for monitoring RNA conformation and dynamics (solution methods and electrophoretic and spectroscopic methods); and modeling tertiary structure: Part B, its companion Volume 318 of Methods in Enzymology, focuses on molecular biology methods. The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the Series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.

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