The Somatotrophic Axis In Brain Function

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Author: Fred Nyberg
Publisher: Elsevier
ISBN: 0080498167
Size: 67.63 MB
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The Somatotrophic Axis In Brain Function by Fred Nyberg


Original Title: The Somatotrophic Axis In Brain Function

The somatotropic axis is one of the major hormonal systems regulating postnatal growth in mammals. It interacts with the central nervous system on several levels. Growth hormone (GH) and insulin-like growth factor-I (IGF-I) receptors are expressed in many brain areas including the hippocampus, pituitary and hypothalamus. GH and IGF-I are important factors in the development and differentiation of the CNS and have protective properties in dementia, as well as in traumatic and ischaemic injury of the CNS. Also GH has an important impact on mood and well-being with GH secretory capacity being reduced in depression. This volume will include chapters (1) on basic knowledge on GH/IGF-1, (2) on localization of GH/IGF-1 and their receptors in the CNS, including blood brain barrier transport of both hormones, (3) on actions of the two hormones on CNS function (basic science), (4) on clinical aspects of GH/IGF-1 in relation to various CNS functions and disorders, and finally (5) on some future perspectives in this area of science. Contents are well balanced and cover a variety of relevant topics from basic to clinical research International selection of authors, with a good representation of the research on growth hormones A timely publication which will be useful to scientists in both basic and clinical research

New Concepts Of Psychostimulants Induced Neurotoxicity

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Author: Hari Shanker Sharma
Publisher: Academic Press
ISBN: 9780080922904
Size: 47.81 MB
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New Concepts Of Psychostimulants Induced Neurotoxicity by Hari Shanker Sharma


Original Title: New Concepts Of Psychostimulants Induced Neurotoxicity

Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research. With recent advancements in new knowledge, it has become evident that psychostimulants and related drugs of abuse are influencing our central nervous system (CNS) remarkably and could alter their function for a longtime. This volume is the first to focus on substance abuse induced brain pathology in the widest sense as it covers alterations in neuronal, glial and endothelial cell functions under the influence of acute or chronic usage of substance abuse.

Growth Hormone Therapy In Pediatrics

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Author: Michael B. Ranke
Publisher: Karger Medical and Scientific Publishers
ISBN: 3805582560
Size: 78.42 MB
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Growth Hormone Therapy In Pediatrics by Michael B. Ranke


Original Title: Growth Hormone Therapy In Pediatrics

For 20 years, KIGS (Pfizer International Growth Database) has provided an outstanding tool for monitoring the use, efficacy and safety of growth hormone (GH) treatment in children with short stature of varying origin. This volume offers a comprehensive update of the continuing experiences in KIGS and is based on data from more than 50 countries and more than 60,000 patients. International experts analyse in detail the basic auxological characteristics of patients and their response to GH treatment for a broad spectrum of growth disorders. These include idiopathic GH deficiency, organic GH deficiency due to a variety of causes such as congenital malformations and syndromes, genetic disorders or treatment for leukaemia or central nervous system tumours and short stature in children born small for gestational age, specific syndromes and systemic disorders. Each growth disorder is also covered by a review of relevant published data by international experts. KIGS has also established itself as a primary source of information about adverse events during long-term GH treatment in children. The recent analysis of KIGS data has revealed no new adverse drug reactions since the 10-year follow-up. Therefore, treatment with GH seems a low-risk intervention in children and adolescents with various growth disorders. The process of developing disease-specific growth response prediction models has been ongoing in KIGS for many years. The available models are accurate, precise and have a relatively high degree of predictive power, although further predictors of the growth response remain to be identified. The KIGS prediction models can be applied prospectively to new patients, enabling their GH therapy to be better tailored and monitored to achieve optimal growth, safety and cost outcomes. The future of KIGS within the era of evidence-based medicine will continue to depend upon the quality of the data reported. Therefore, the commitment of participating physicians will continue to be a decisive element. The ongoing recognition of the importance of valid safety and efficacy information in the practice of paediatric endocrinology is exemplified by this valuable international collaboration of clinicians and the pharmaceutical community.

Traumatic Brain Injury

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Author: Mark J. Ashley
Publisher: CRC Press
ISBN: 143984982X
Size: 55.92 MB
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Traumatic Brain Injury by Mark J. Ashley


Original Title: Traumatic Brain Injury

Since the bestselling second edition was published almost a decade ago, the field of brain injury treatment has undergone tremendous change, largely impacting access to treatment. But, while the healthcare marketplace has evolved, the needs of brain injury victims remain the same. With updated and expanded clinical coverage, Traumatic Brain Injury: Rehabilitation, Treatment, and Case Management, Third Edition delineates a broad spectrum of advanced theoretical clinical constructs and detailed diagnostic and treatment interventions for traumatic brain injury. Details Specific Diagnostic and Treatment Approaches for Nearly All Aspects of Dysfunction Observed Following Brain Injury With contributions from more than 50 authorities in both academia and industry, this highly respected text stands apart as a clinical guide to rehabilitative treatment of persons with traumatic brain injury following the acute phase of treatment. It provides a concise source of information about the scientific and therapeutic realms involved in the rehabilitation of a person with traumatic brain injury, specifically as they relate to persistent deficits. The book also details long-term consequences of brain injury and effective approaches to vocational rehabilitation and case management. Widening coverage from the previous edition, this book includes details on: Metabolic and bioenergetic factors in brain injury Neuroendocrine dysfunction following brain injury Blast injury Ethical issues in treatment of brain injury Neuropharmacological and neuropsychological interventions following brain injury Interventions for the minimally conscious patient Dietary and exercise considerations after brain injury Traumatic Brain Injury: Rehabilitation, Treatment, and Case Management, Third Edition is a complete source of pharmacological, anatomical, and physiological information for basic therapeutic rationales that are often not well understood in the field. It is an ideal reference for both new and experienced clinicians.

The Brain And Host Defense

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Author:
Publisher: Elsevier
ISBN: 9780444535450
Size: 47.92 MB
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The Brain And Host Defense by


Original Title: The Brain And Host Defense

It is now well recognized that the brain, and especially the hypothalamus, plays an important role in the regulation of immune reactions and inflammation. This book aims to review our current state of knowledge of this important field. Key historical findings are presented, and the reciprocal interactions between the brain and the immune system are examined. Particular emphasis is placed on inflammation, a critical host defense reaction that serves as an effector response for both the adaptive and innate immune systems. Mechanisms implicated in brain defense, as well as in more general host defense, are discussed. The regulatory influences of the brain on inflammatory responses are included with particular reference to the role of the hypothalamus, which is also the main director the hormonal regulation of immune/inflammatory. Gender-related differences in immune responsiveness, circadian modulator of immune responses, and evidence that behavioral conditioning (e.g. reward) of immune responses is possible are used as examples to reinforce the notion that the neuroendocrine system exerts a fundamental and complex regulatory influence on the immune system. * Presents timely issues such as immunological aspects of the blood-brain-barrier and the role of inflammatory mediators in the evolution of strokes and degenerative diseases * Includes analysis of the role of the brain in the adaptive responses to disease * Evaluates the argument that further knowledge of the influence of the brain on the immune system will provide new insights to the pathophysiology infectious and autoimmune diseases

Hormones Brain And Behavior Five Volume Set

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Author:
Publisher: Elsevier
ISBN: 0080534155
Size: 56.81 MB
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Hormones Brain And Behavior Five Volume Set by


Original Title: Hormones Brain And Behavior Five Volume Set

Hormones, Brain and Behavior, Third Edition offers a state-of-the-art overview of hormonally-mediated behaviors, including an extensive discussion of the effects of hormones on insects, fish, amphibians, birds, rodents, and humans. Entries have been carefully designed to provide a valuable source of information for students and researchers in neuroendocrinology and those working in related areas, such as biology, psychology, psychiatry, and neurology. This third edition has been substantially restructured to include both foundational information and recent developments in the field. Continuing the emphasis on interdisciplinary research and practical applications, the book includes articles aligned in five main subject sections, with new chapters included on genetic and genomic techniques and clinical investigations. This reference provides unique treatment of all major vertebrate and invertebrate model systems with excellent opportunities for relating behavior to molecular genetics. The topics cover an unusual breadth (from molecules to ecophysiology), ranging from basic science to clinical research, making this reference of interest to a broad range of scientists in a variety of fields. Key Features * Contributors from 16 different countries and more than 70 institutions * Unlike any other hormone reference on the market Hormones, Brain and Behavior addresses hormone effects in all major vertebrate and non-vertebrate models * A timely, current reference on an emerging field with each chapter providing an in-depth exploration of the topic * Discusses molecular aspects of hormone function, systems, development, and hormone-related diseases * Addresses hormone effects in both the developing and adult nervous system Topics include: * Mammalian and Non-mammalian Hormone-behavior Systems * Cellular and Molecular Mechanisms of Hormone Actions on Behavior * Development of Hormone-dependent Neuronal Systems * Hormone/Behavior Relations of Clinical Importance

Handbook Of Child And Adolescent Psychiatry Basic Psychiatric Science And Treatment

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Author: Joseph D. Noshpitz
Publisher: John Wiley & Sons
ISBN: 9780471193319
Size: 30.13 MB
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Handbook Of Child And Adolescent Psychiatry Basic Psychiatric Science And Treatment by Joseph D. Noshpitz


Original Title: Handbook Of Child And Adolescent Psychiatry Basic Psychiatric Science And Treatment

This volume of the Handbook introduces the basic science of child and adolescent psychiatry and presents a myriad of treatment options available to psychiatrists. These include clinical treatments, such as diet and drug therapy, hypnotherapy and biofeedback; residential or day treatment options; group and family therapy; aggressive interventions such as therapeutic foster placement or adoption; creative treatments, such as art and music therapy; and rehabilitative therapy, including vocational therapy, educational therapy and therapeutic camping.

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