Transmembrane Receptors And Channels

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Author: A.G. Lee
Publisher: Elsevier
ISBN: 9780080543154
Size: 72.95 MB
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Transmembrane Receptors And Channels by A.G. Lee


Original Title: Transmembrane Receptors And Channels

Volume 6 of Biomembranes covers transmembrane receptors and channels. A particularly important role for the membrane is that of passing messages between a cell and its environment. Part I of this volume covers receptors for hormones and growth factors. Here, as in so many other areas of cell biology, the application of the methods of molecular biology have led to the recognition of a number of families of receptors. Typically, such receptors contain an extracellular ligand binding domain, a transmembrane domain, and an intracellular catalytic domain whose activation, as a result of ligand binding, leads to generation of second messengers within the cell and stimulation of a range of cytosolic enzymes. An alternative signaling strategy, exploited in particular in the nervous system, is to use ion channels to allow controlled movement of monovalent (Na+, K+) or divalent (Ca2+) cations in or out of the cell, resulting in changes in membrane potential or alterations in the intracellular concentration of Ca2+. Part II of this volume is concerned with these ion channels and with other, often simpler, ion channel systems whose study can throw light on channel mechanism.

Thermodynamics Of Membrane Receptors And Channels

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Author: Meyer B. Jackson
Publisher: CRC Press
ISBN: 9780849369087
Size: 76.78 MB
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Thermodynamics Of Membrane Receptors And Channels by Meyer B. Jackson


Original Title: Thermodynamics Of Membrane Receptors And Channels

Thermodynamics of Membrane Receptors and Channels synthesizes a wealth of new information regarding the biophysics of membrane proteins. New insights provided by molecular genetics, single channel recording, and high resolution structural techniques are discussed from a conceptual perspective. Basic theoretical topics are introduced, developed, and then extensively illustrated with recent results from the literature or data from the authors' own laboratories. Theoretical and experimental information is incorporated into in-depth discussions of ion permeation mechanisms, ion channel and receptor conformational changes, aggregate activity of complexes of lipids and proteins, and how coupling is achieved between different energy modes in the many transduction systems residing in biomembranes. Thermodynamics of Membrane Receptors and Channels will be valuable both as a learning aid and a reference for biophysicists, neuroscientists, cell biologists, physiologists, and other researchers investigating any aspects of biomembranes.

Membrane Receptors Channels And Transporters In Pulmonary Circulation

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Author: Jason X. -J. Yuan
Publisher: Springer Science & Business Media
ISBN: 1607615002
Size: 21.65 MB
Format: PDF
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Membrane Receptors Channels And Transporters In Pulmonary Circulation by Jason X. -J. Yuan


Original Title: Membrane Receptors Channels And Transporters In Pulmonary Circulation

Membrane Receptors, Channels and Transporters in Pulmonary Circulation is a proceeding of the 2008 Grover Conference (Lost Valley Ranch and Conference Center, Sedalia, Colorado; September 3-7, 2008), which provided a forum for experts in the fields of those receptors, channels and transporters that have been identified as playing key roles in the physiology and pathophysiology of the pulmonary circulation. The book rigorously addresses: i) recent advances in our knowledge of receptors, channels and transporters and their role in regulation of pulmonary vascular function; ii) how modulation of expression and function of receptors, channels and transporters and their interrelationships contribute to the pathogenesis of pulmonary vascular disease; and iii) the therapeutic opportunities that may be revealed by enhancing our understanding of this area. The overall goal was to explore the mechanisms by which specific receptors, channels and transporters contribute to pulmonary vascular function in both health and disease, and how this knowledge may lead to novel interventions in lung dysplasia, pulmonary edema, lung injury, and pulmonary and systemic hypertension to reduce and prevent death from lung disease. Membrane Receptors, Channels and Transporters in Pulmonary Circulation is divided into six parts. Part 1 (Ion Channels in the Pulmonary Vasculature: Basics and New Findings) is designated for basic knowledge and recent findings in the research field of ion channels in pulmonary circulation. There are five chapters in Part I discussing the function, expression, distribution and regulation of various ion channels present in pulmonary vascular smooth muscle cells and how these channels are integrated to regulate intracellular Ca2+ and cell functions. Part II (TRP Channels in the Pulmonary Vasculature: Basics and New Findings) is composed of five chapters that are exclusively designed to discuss the role of a recently identified family of cation channels, transient receptor potential (TRP) channels, in the regulation of pulmonary vascular tone and arterial structure. Part III (Pathogenic Role of Ion Channels in Pulmonary Vascular Disease) includes four chapters that discuss how abnormal function and expression of various ion channels contribute to changes in cell functions and the development of pulmonary hypertension. Part IV (Receptors and Signaling Cascades in Pulmonary Arterial Hypertension) consists of five chapters devoted to the role of bone morphogenetic protein receptors, Notch receptors, serotonin receptors, Rho kinase and vascular endothelial growth factor receptors in the development of pulmonary arterial hypertension. Part V (Receptors and Transporters: Role in Cell Function and Hypoxic Pulmonary Vasoconstriction) includes four chapters designed to illustrate the potential mechanisms involved in oxygen sensing and hypoxia-induced pulmonary vasoconstriction and hypertension. Part VI (Targeting Ion Channels and Membrane Receptors in Developing Novel Therapeutic Approaches for Pulmonary Vascular Disease) consists five chapters which discuss the translational research involving on membrane receptors, channels and transporters, including their potential as novel drug targets. We hope that Membrane Receptors, Channels and Transporters in Pulmonary Circulation will allow readers to foster new concepts and new collaborations and cooperations among investigators so as to further understand the role of receptors, channels and transporters in lung pathophysiology. The ultimate goal is to identify new mechanisms of disease, as well as new therapeutic targets for pulmonary vascular diseases. An additional outcome should be enhanced understanding of the role of these entities in systemic vascular pathophysiology, since the conference will include researchers and clinicians with interests in both pulmonary and systemic circulations.

Cholesterol Regulation Of Ion Channels And Receptors

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Author: Irena Levitan
Publisher: John Wiley & Sons
ISBN: 1118342305
Size: 19.92 MB
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Cholesterol Regulation Of Ion Channels And Receptors by Irena Levitan


Original Title: Cholesterol Regulation Of Ion Channels And Receptors

Examines new research on the role of cholesterol in regulating ion channels and receptors and its effect on health Drawing together and analyzing all the latest research findings, this book explores the role of cholesterol in the regulation of ion channels and receptors, including its pathological effects. It is the first book to comprehensively describe the complex mechanisms by which cholesterol regulates two major classes of membrane proteins. Moreover, it sheds new light on how cholesterol affects essential cellular functions such as the contraction of the heart, propagation of nerve impulses, and regulation of blood pressure and kidney function. Written and edited by leading pioneers in the field, Cholesterol Regulation of Ion Channels and Receptors is divided into three parts: Part I, Cholesterol Regulation of Membrane Properties, introduces the heterogeneity of cholesterol distribution in biological membranes and the physical and biological implications of the formation of cholesterol-rich membrane domains. Part II, Cholesterol Regulation of Ion Channels, examines the mechanisms underlying cholesterol sensitivities of ion channels, including the regulation of ion channels by cholesterol as a boundary lipid. Part III, Cholesterol Regulation of Receptors, explores the latest discoveries concerning how cholesterol regulates distinct types of receptors, including G-protein coupled receptors, LDL and scavenger receptors, and innate immune system receptors. Increased levels of cholesterol represent a major health risk. Understanding cholesterol regulation of ion channels and receptors is essential for facilitating the development of new therapeutic strategies to alleviate the impact of pathological cholesterol conditions. With this book as their guide, readers have access to the most current knowledge in the field.

Handbook Of Receptors And Channels

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Author: R. Alan North
Publisher: CRC Press
ISBN: 9780849383229
Size: 57.20 MB
Format: PDF
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Handbook Of Receptors And Channels by R. Alan North


Original Title: Handbook Of Receptors And Channels

This authoritative and comprehensive volume presents a perspective in the molecular and cellular diversity of membrane ion channels. Written in an accessible format, it depicts the structure and function of each of the known classes of ion channels. Each chapter provides amino acid sequences, including data base accession numbers; views of secondary, tertiary and quaternary channel structure; and evolutionary relationships among channels.

Medical Sciences E Book

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Author: Jeannette Naish
Publisher: Elsevier Health Sciences
ISBN: 0702052493
Size: 14.42 MB
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Medical Sciences E Book by Jeannette Naish


Original Title: Medical Sciences E Book

An integrated approach to teaching basic sciences and clinical medicine has meant that medical students have been driven to a range of basic science textbooks to find relevant information. Medical Sciences is designed to do the integration for you. In just one book, the diverse branches of medical science are synthesised into the appropriate systems of the human body, making this an invaluable aid to approaching the basics of medicine within in a clinical context. . An integrated approach to teaching basic sciences and clinical medicine has meant that medical students have been driven to a range of basic science textbooks to find relevant information. Medical Sciences does the integration for you. In just one book, the diverse branches of medical science are synthesised into the appropriate systems of the human body, making this an invaluable aid to approaching the basics of medicine within in a clinical context. Eleven new contributors. Completely new chapters on Biochemistry and cell biology, Genetics, The nervous system, Bones, muscle and skin, Endocrine and reproductive systems, The cardiovascular system, The renal system and Diet and nutrition. Completely revised and updated throughout with over 35 new illustrations . Expanded embryology sections with several new illustrations.

An Introduction To Neuroendocrinology

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Author: Richard E. Brown
Publisher: Cambridge University Press
ISBN: 9780521426657
Size: 75.57 MB
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An Introduction To Neuroendocrinology by Richard E. Brown


Original Title: An Introduction To Neuroendocrinology

This book is designed as an introductory text in neuroendocrinology; the study of the interaction between the brain and endocrine system and the influence of this on behaviour. The endocrine glands, pituitary gland and hypothalamus and their interactions and hormones are discussed. The action of steroid and thyroid hormone receptors and the regulation of target cell response to hormones is examined. The function of neuropeptides is discussed with respect to the neuroendocrine system and behaviour. The neuroimmune system and lymphokines are described and the interaction between the neuroendocrine and neuroimmune systems discussed. Finally, methods for studying hormonal influences on behaviour are outlined. Each chapter has review and essay questions designed for advanced students and honours or graduate students with a background in neuroscience, respectively.

Ion Channels And Disease

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Author: Frances M. Ashcroft
Publisher: Academic Press
ISBN: 0080535216
Size: 24.33 MB
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Ion Channels And Disease by Frances M. Ashcroft


Original Title: Ion Channels And Disease

Ion channels are membrane proteins that act as gated pathways for the movement of ions across cell membranes. They play essential roles in the physiology of all cells. In recent years, an ever-increasing number of human and animal diseases have been found to result from defects in ion channel function. Most of these diseases arise from mutations in the genes encoding ion channel proteins, and they are now referred to as the channelopathies. Ion Channels and Disease provides an informative and up-to-date account of our present understanding of ion channels and the molecular basis of ion channel diseases. It includes a basic introduction to the relevant aspects of molecular biology and biophysics and a brief description of the principal methods used to study channelopathies. For each channel, the relationship between its molecular structure and its functional properties is discussed and ways in which genetic mutations produce the disease phenotype are considered. This book is intended for research workers and clinicians, as well as graduates and advanced undergraduates. The text is clear and lively and assumes little knowledge, yet it takes the reader to frontiers of what is currently known about this most exciting and medically important area of physiology. Key Features * Introduces the relevant aspects of molecular biology and biophysics * Describes the principal methods used to study channelopathies * Considers single classes of ion channels with summaries of the physiological role, subunit composition, molecular structure and chromosomal location, plus the relationship between channel structure and function * Looks at those diseases associated with defective channel structures and regulation, including mutations affecting channel function and to what extent this change in channel function can account for the clinical phenotype

Pharmacology For Rehabilitation Professionals

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Author: Barbara Gladson
Publisher: Elsevier Health Sciences
ISBN: 1437707564
Size: 74.14 MB
Format: PDF, ePub
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Pharmacology For Rehabilitation Professionals by Barbara Gladson


Original Title: Pharmacology For Rehabilitation Professionals

Now fully revised and updated, Dr. Barbara Gladson's Pharmacology for Rehabilitation Professionals, 2nd Edition, remains your best resource for understanding how various drugs affect patients during therapeutic exercise and rehabilitation. Using case studies and engaging activities, it helps you apply essential pharmacology information directly to rehabilitation practice. New chapters, a new reader-friendly design, new artwork, and more enhance the text and bring you up to date with both basic pharmacologic principles as well as the mechanism of action and side effects of drugs commonly seen in rehabilitation practice. Helps you develop effective exercise programs by providing drug/exercise interactions from a pharmacokinetics perspective. You willl clearly see the implications for exercise for each specific condition and medication. Presents case studies in every chapter that demonstrate the effects of various drugs on the diagnosis, prognosis, and interventions in physical therapy, so you can more easily monitor patients for adverse drug effects. Features engaging activities in every chapter, ranging from patient interviews to challenging, real-life questions, helping you retain and apply what you've learned. Encourages you to use the latest research in your clinical decision making with evidence-based content incorporated throughout. Simplifies the complex topic of pharmacokinetics so that you will fully understand how it affects your individual patients and your care plans. Guides you in using the Internet for online drug information with references to specific sites, and when and how to use them to their fullest potential. Discusses lifespan considerations such as age, physical differences, and obesity, as well as the latest information on diabetes and glucose testing. A new chapter on Complementary and Alternative Medicine in Pharmacology covers popular herbal and alternative products used to promote health, as well as herbal remedies used during menopause and in the treatment of cancer, helping you recognize the impact of herbals on your patients' symptoms and response to therapy. A new chapter on Drugs Affecting the Integumentary System discusses skin disorders and their pharmacological treatment, prophylactic and debriding agents, antiseptics, and more. A new chapter on Nutrition and Pharmacology provides current information on vitamins and minerals, enteral and parenteral nutrition, and food and drug interactions -- important topics that affect rehabilitation outcomes. Updated drug information and new drugs are added throughout the text, keeping you up to date with current pharmacological information as it pertains to rehabilitation.

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